Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411316 | 0.94 | RORC (0.35) | RORCTLR7LMNACHRM2CHRM1 | |
| SCHEMBL7142155 | 0.91 | CHRM2 (0.35) | LMNACHRM2CHRM1CHRM3TPSAB1 | |
| SCHEMBL7150781 | 0.89 | HTR2A (0.37) | LMNATP53 | |
| SCHEMBL7149405 | 0.88 | TPSAB1 (0.36) | LMNACHRM2CHRM1CHRM3TPSAB1 | |
| SCHEMBL7024701 | 0.86 | PDK1 (0.38) | TLR7LMNATPSAB1TLR9TLR8 | |
| SCHEMBL7148789 | 0.85 | CCR5 (0.36) | TPSAB1 | |
| SCHEMBL7148752 | 0.85 | CCR5 (0.36) | LMNACHRM2CHRM1CHRM3 | |
| SCHEMBL4404630 | 0.84 | LMNA (0.38) | LMNACHRM2CHRM1CHRM3TPSAB1 | |
| SCHEMBL4403365 | 0.82 | TP53 (0.36) | LMNATP53 | |
| SCHEMBL4411320 | 0.82 | TLR7 (0.35) | RORCTLR7LMNACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |