Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 5/20 | 0.36 |
| ▸ | FASN | P49327 | 6/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396163 | 0.93 | CHRM2 (0.39) | CCR5FASNCHRM2CHRM1CHRM3 | |
| SCHEMBL7149405 | 0.92 | TPSAB1 (0.36) | CHRM2CHRM1CHRM3LMNA | |
| SCHEMBL7024701 | 0.90 | PDK1 (0.38) | CCR5LMNA | |
| SCHEMBL7142155 | 0.90 | CHRM2 (0.35) | CCR5CHRM2CHRM1CHRM3LMNA | |
| SCHEMBL7148789 | 0.87 | CCR5 (0.36) | CCR5 | |
| SCHEMBL7150781 | 0.85 | HTR2A (0.37) | LMNA | |
| SCHEMBL7148965 | 0.85 | RORC (0.33) | CHRM2CHRM1CHRM3LMNA | |
| SCHEMBL4404848 | 0.85 | LMNA (0.41) | CCR5FASNCHRM2CHRM1CHRM3 | |
| SCHEMBL4412034 | 0.85 | LMNA (0.40) | LMNA | |
| SCHEMBL4396166 | 0.83 | FASN (0.37) | CCR5FASNCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |