SCHEMBL7044409

SCHEMBL7044409

COc1nn(-c2cccc(N(Cc3ccccc3)Cc3ccccc3)c2)c(=O)o1

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 9/20 0.62
ABHD16A O95870 2/20 0.54
BCHE P06276 1/20 0.53
LIPC P11150 1/20 0.53
ACHE P22303 1/20 0.53
LIPE Q05469 1/20 0.53
FAAH O00519 7/20 0.52
ABHD6 Q9BV23 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7044238 0.79 BCHE (0.81) MGLLABHD16ABCHELIPCACHE
SCHEMBL11620781 0.78 FAAH (0.78) MGLLABHD16ABCHELIPCACHE
SCHEMBL6552790 0.78 MGLL (0.74) MGLLABHD16ABCHELIPCACHE
SCHEMBL7047523 0.74 MGLL (0.67) MGLLABHD16ABCHELIPCACHE
Trifluoroacetic Acid SCHEMBL6600717 0.72 MGLL (0.52) MGLLABHD16ABCHELIPCACHE
SCHEMBL6551894 0.71 ACHE (0.65) MGLLABHD16ABCHELIPCACHE
SCHEMBL6551854 0.71 FAAH (0.74) MGLLABHD16ALIPCLIPEFAAH
Trifluoroacetic Acid SCHEMBL6602639 0.70 MGLL (0.52) MGLLABHD16ABCHELIPCACHE
SCHEMBL7043147 0.70 MGLL (0.81) MGLLABHD16ABCHELIPCACHE
SCHEMBL6552559 0.69 BCHE (1.00) MGLLABHD16ABCHELIPCACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase AVENTIS PHARMA DEUTSCHLAND GMBH 2003-12-25 US disclosed
US-6369088-B2 ANTIDIABETIC AGENTS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-09 US disclosed
US-20010031772-A1 Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use as pharmaceuticals SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010031772-A1 Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use as pharmaceuticals CNR1, PTGER1, CNR2 MGLL 1542/4885ABHD16A 1922/4885BCHE 1676/4885
US-20030236288-A1 Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase PNLIP, CEL, LIPE MGLL 10/4885ABHD16A 62/4885BCHE 626/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.