Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.32 |
| ▸ | TUBB | P07437 | 3/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436133 | 0.87 | CYP2C9 (0.39) | CSNK2A1HIPK2NR4A2MAP2K1CYP2C9 | |
| SCHEMBL7063086 | 0.86 | NR4A2 (0.40) | CSNK2A1HIPK2NR4A2MAP2K1CYP2C9 | |
| SCHEMBL3016851 | 0.80 | PIM3 (0.46) | NR4A2MAP2K1CYP2C9KDM4EALDH1A1 | |
| Potassium Ion SCHEMBL1762974 | 0.78 | KDM5A (0.40) | CSNK2A1HIPK2NR4A2ALDH1A1BRPF1 | |
| SCHEMBL20673981 | 0.74 | PDPK1 (0.35) | CSNK2A1HIPK2CYP2C9KDM4EALDH1A1 | |
| SCHEMBL8407067 | 0.74 | GABRA1 (0.44) | CYP2C9KDM4EALDH1A1HPGDCPT1A | |
| SCHEMBL8408258 | 0.73 | CLEC4M (0.62) | KDM4EALDH1A1HPGD | |
| SCHEMBL30781511 | 0.71 | ALDH1A1 (0.39) | KDM4EALDH1A1MTNR1ADYRK1ARAB9A | |
| SCHEMBL23498199 | 0.71 | TDO2 (0.41) | KDM4EALDH1A1HPGDKDM5AKDM4C | |
| SCHEMBL29723651 | 0.71 | TDO2 (0.41) | KDM4EALDH1A1HPGDKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030181463-A1 | Antiviral azaindole derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181463-A1 | Antiviral azaindole derivatives | ZC3HAV1, MAVS, AZI2 | CSNK2A1 3411/4885HIPK2 673/4885NR4A2 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.