Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753726 | 0.83 | LMNA (0.45) | DHFRRAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL2655184 | 0.82 | DHFR (0.41) | PTGS2DHFRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL19002781 | 0.80 | PTGS2 (0.51) | PTGS2DHFRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL10905449 | 0.80 | RAB9A (0.41) | PTGS2DHFRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL30417867 | 0.78 | PTGS2 (0.51) | PTGS2DHFRALDH1A1 | |
| SCHEMBL21740872 | 0.76 | DHFR (0.43) | PTGS2DHFRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL18997259 | 0.76 | DHFR (0.40) | PTGS2DHFRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL10144132 | 0.75 | PTGS2 (0.47) | PTGS2DHFRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL5576227 | 0.75 | CYP1A2 (0.50) | DHFRRAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL4267829 | 0.74 | ALDH1A1 (0.61) | PTGS2RAB9ASMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1437598-A | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 2003-08-20 | — | — | CN | disclosed |
| US-20030050307-A1 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 2003-03-13 | — | — | US | disclosed |
| EP-1246818-A1 | NOVEL INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049680-A1 | NOVEL INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030050307-A1 | Novel indole derivatives | HTR1A, HTR3C, HTR2C | PTGS2 1397/4885DHFR 1679/4885RAB9A 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.