SCHEMBL7100648

SCHEMBL7100648

O=c1c2ccccc2nc(C(Cc2ccccc2)c2ccccc2)n1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.44

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CXCR3 P49682 16/20 0.44
ALDH1A1 P00352 1/20 0.44
MLYCD O95822 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7016853 0.84 MLYCD (0.43) CXCR3ALDH1A1MLYCD
SCHEMBL7017597 0.83 CXCR3 (0.44) CXCR3ALDH1A1MLYCD
SCHEMBL7020798 0.83 KCNH2 (0.50) CXCR3MLYCD
SCHEMBL7023261 0.80 ALDH1A1 (0.70) ALDH1A1NPC1RAB9A
SCHEMBL7023859 0.79 ALDH1A1 (0.56) ALDH1A1NPC1RAB9A
SCHEMBL7016812 0.77 TP53 (0.46) ALDH1A1NPC1RAB9A
SCHEMBL7018385 0.77 TP53 (0.46) ALDH1A1NPC1RAB9A
SCHEMBL7014520 0.76 ALDH1A1 (0.52) ALDH1A1NPC1RAB9A
SCHEMBL7100250 0.76 MEN1 (0.60) ALDH1A1RAB9A
SCHEMBL7020723 0.76 TP53 (0.43) CXCR3MLYCDNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003106435-A1 FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF SANKYO COMPANY, LIMITED (JP) 2003-12-24 WO disclosed