Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL7101299 | 0.85 | ALDH1A1 (0.42) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| SCHEMBL543678 | 0.78 | ALDH1A1 (0.69) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| Tromethamine SCHEMBL5702541 | 0.78 | LMNA (0.43) | ALDH1A1TDP1KMT2AMEN1LMNA | |
| Tromethamine SCHEMBL6477534 | 0.72 | S1PR1 (0.44) | KMT2AMEN1LMNARAB9ANPC1 | |
| Tromethamine SCHEMBL6787515 | 0.72 | IDO1 (0.54) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| Tromethamine SCHEMBL8920729 | 0.70 | MEN1 (0.36) | KMT2AMEN1LMNA | |
| Tromethamine SCHEMBL1278460 | 0.69 | MEN1 (0.62) | KMT2AMEN1LMNA | |
| Tromethamine SCHEMBL8772229 | 0.69 | MEN1 (0.62) | KMT2AMEN1LMNA | |
| Tromethamine SCHEMBL1759319 | 0.68 | MEN1 (0.71) | MAPTKMT2AMEN1LMNA | |
| Trifluoromethanesulfonic Acid SCHEMBL4575017 | 0.68 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5569784-A | FINE PATTERN; PREVENTS POST-EXPOSURE DELAY | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-10-29 | — | — | US | claimed |