Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL9809003 | 0.90 | — | — | |
| Ether SCHEMBL17291816 | 0.90 | — | — | |
| Ether SCHEMBL28457488 | 0.90 | — | — | |
| Ether SCHEMBL11882966 | 0.90 | — | — | |
| Ether SCHEMBL9147509 | 0.90 | — | — | |
| Ether SCHEMBL6 | 0.89 | — | — | |
| Ether SCHEMBL9248674 | 0.89 | ALDH1A1 (0.47) | — | |
| Ether SCHEMBL21406 | 0.89 | ALDH1A1 (0.47) | — | |
| Ether SCHEMBL8160191 | 0.89 | ALDH1A1 (0.47) | — | |
| Ether SCHEMBL9248046 | 0.89 | ALDH1A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103119026-B | Preparation method and the intermediate in this preparation method of the pan-CDK inhibitor of formula (I) | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-19 | — | — | CN | disclosed |
| CN-103119026-A | Process for preparing pan-cdk inhibitors of the formula (l), and intermediates in the preparation | BAYER IP GMBH | 2013-05-22 | — | — | CN | disclosed |
| US-6828450-B2 | Inhibiting nucleoside transport, inducing DNA fragmentation, inhibiting nucleic acid synthesis, inhibiting protein synthesis, decreasing the proliferation of cancer cells or decreasing the viability of cancer cells | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION | 2004-12-07 | — | — | US | disclosed |
| US-20020091163-A1 | Triptycene analogs | KANSAS STATE UNIVERISTY RESEARCH FOUNDATION | 2002-07-11 | — | — | US | disclosed |
| WO-2002028808-A1 | TRIPTYCENE ANALOGS | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2002-04-11 | — | — | WO | disclosed |
| CN-1093363-A | The pyrazoles that replaces | PFIZER (US) | 1994-10-12 | — | — | CN | disclosed |