Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 10/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801076 | 0.89 | TET2 (0.52) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL18334357 | 0.89 | TET2 (0.52) | TET2KDM4AKDM4CKDM2ATET3 | |
| Lindane SCHEMBL10587433 | 0.79 | GABRP (0.35) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL18334377 | 0.75 | MAPT (0.56) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL18334378 | 0.75 | MAPT (0.56) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL22826568 | 0.73 | MAPT (0.59) | FOLH1MAPT | |
| SCHEMBL30816384 | 0.71 | MAPT (0.63) | MAPT | |
| SCHEMBL8639483 | 0.71 | MAPT (0.63) | MAPT | |
| SCHEMBL3510953 | 0.70 | KMT2A (0.56) | FOLH1CYP1A2GRM3GRM8GRM6 | |
| SCHEMBL21443815 | 0.70 | GABRP (0.46) | TET2KDM4AKDM4CKDM2ATET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278909-B2 | Amide-extended crosslinking compounds and methods for use thereof | DESIGNER MOLECULES, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-8637611-B2 | Amide-extended crosslinking compounds and methods for use thereof | DESIGNER MOLECULES, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130338313-A1 | AMIDE-EXTENDED CROSSLINKING COMPOUNDS AND METHODS FOR USE THEREOF | DESIGNER MOLECULES, INC. (US) | 2013-12-19 | — | — | US | disclosed |
| US-20130199724-A1 | CURATIVES FOR EPOXY COMPOSITIONS | DESIGNER MOLECULES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203895-A1 | CURING AGENTS FOR EPOXY RESINS | DESIGNER MOLECULES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130012620-A1 | CURING AGENTS FOR EPOXY RESINS | DESIGNER MOLECULES, INC. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8288591-B2 | Curing agents for epoxy resins | DESIGNER MOLECULES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8287686-B2 | Derivatives of poly(styrene-co-allyl alcohol) and methods for use thereof | DESIGNER MOLECULES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8217120-B2 | Functionalized styrene oligomers and polymers | DESIGNER MOLECULES, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-20120049106-A1 | MALEIMIDE-FUNCTIONAL MONOMERS IN AMORPHOUS FORM | DESIGNER MOLECULES, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2010019832-A2 | AMIDE-EXTENDED CROSSLINKING COMPOUNDS AND METHODS FOR USE THEREOF | DESIGNER MOLECULES, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
| US-20100041823-A1 | NOVEL SILOXANE MONOMERS AND METHODS FOR USE THEREOF | DESIGNER MOLECULES, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041803-A1 | THERMOSETTING HYPERBRANCHED COMPOSITIONS AND METHODS FOR USE THEREOF | DESIGNER MOLECULES, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041832-A1 | FUNCTIONALIZED STYRENE OLIGOMERS AND POLYMERS | DESIGNER MOLECULES, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20080017308-A1 | Derivatives of poly(styrene-co-allyl alcohol) and methods for use thereof | DESIGNER MOLECULES, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20070295454-A1 | Reworkable compositions and methods for use thereof | EDWARDS MAURY | 2007-12-27 | — | — | US | disclosed |
| WO-2007142654-A1 | REWORKABLE COMPOSITIONS AND METHODS FOR USE THEREOF | ADVANCED APPLIED ADHESIVES (US) | 2007-12-13 | — | — | WO | disclosed |
| US-20060069232-A1 | Underfill compositions and methods for use thereof | DESIGNER MOLECULES, INC. | 2006-03-30 | — | — | US | disclosed |
| US-7009009-B1 | Fluxing underfill compositions | HENKEL CORPORATION (US) | 2006-03-07 | — | — | US | disclosed |
| US-6667194-B1 | Method of bonding die chip with underfill fluxing composition | HENKEL LOCTITE CORPORATION | 2003-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041823-A1 | NOVEL SILOXANE MONOMERS AND METHODS FOR USE THEREOF | ILK, ESD, GFER | TET2 227/4885KDM4A 54/4885KDM4C 203/4885 |
| US-20100041832-A1 | FUNCTIONALIZED STYRENE OLIGOMERS AND POLYMERS | PFAS, FDFT1, AOX1 | TET2 318/4885KDM4A 1488/4885KDM4C 1670/4885 |
| US-20130012620-A1 | CURING AGENTS FOR EPOXY RESINS | DOT1L, EHMT1, ASH1L | TET2 215/4885KDM4A 14/4885KDM4C 13/4885 |
| US-20100041803-A1 | THERMOSETTING HYPERBRANCHED COMPOSITIONS AND METHODS FOR USE THEREOF | PAICS, PUF60, PARG | TET2 1219/4885KDM4A 839/4885KDM4C 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.