Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 9/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrolipoic Acid SCHEMBL715539 | 0.83 | NFKB1 (0.33) | CA1NFKB1 | |
| SCHEMBL7054829 | 0.74 | FABP3 (0.53) | CA1FABP3HDAC3HDAC1HDAC2 | |
| Adipic Acid SCHEMBL107905 | 0.74 | CA1 (0.67) | CA1FABP3HDAC3HDAC1HDAC2 | |
| SCHEMBL5696140 | 0.71 | — | — | |
| Sebacic Acid SCHEMBL306520 | 0.71 | CA1 (0.63) | CA1FABP3HDAC3HDAC1HDAC2 | |
| SCHEMBL11046980 | 0.71 | CA1 (0.63) | CA1FABP3HDAC3HDAC1HDAC2 | |
| SCHEMBL6053545 | 0.71 | CA1 (0.63) | CA1FABP3HDAC3HDAC1HDAC2 | |
| SCHEMBL20577558 | 0.71 | CA1 (0.63) | CA1FABP3HDAC3HDAC1HDAC2 | |
| SCHEMBL8325989 | 0.71 | CA1 (0.63) | CA1FABP3HDAC3HDAC1HDAC2 | |
| Octanedioate SCHEMBL188028 | 0.71 | CA1 (0.63) | CA1FABP3HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9795558-B2 | Depilatory formulations and methods of using same | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2017-10-24 | — | — | US | claimed |
| US-9573001-B2 | Depilatory composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2017-02-21 | — | — | US | claimed |
| EP-2155808-B1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | ESSILOR INT (COMPAGNIE GÉNÉRALE D'OPTIQUE) (FR) | 2016-12-14 | — | — | EP | claimed |
| US-9110223-B2 | Method for treating the surface of a substrate based on sulphur polymer, intended to be covered with a coating | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2015-08-18 | — | — | US | claimed |
| US-20150202140-A1 | Depilatory Formulations And Methods Of Using Same | RECKITT & COLMAN (OVERSEAS) HEALTH LIMITED (GB) | 2015-07-23 | — | — | US | claimed |
| EP-2355788-B1 | DEPILATORY COMPOSITION | RECKITT & COLMAN OVERSEAS (GB) | 2014-02-12 | — | — | EP | claimed |
| JP-2010529275-A | — | — | 2010-08-26 | — | — | JP | claimed |
| US-20100189889-A1 | Method for Treating the Surface of a Substrate Based on Sulphur Polymer, Intended to be Covered with a Coating | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2010-07-29 | — | — | US | claimed |
| EP-2155808-A1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | Essilor International (Compagnie Générale D'Optique) (FR) | 2010-02-24 | — | — | EP | claimed |
| US-20100028392-A1 | Personal Care Article | RECKITT BENCKISER (UK) LIMITED (GB) | 2010-02-04 | — | — | US | claimed |
| EP-2010128-A1 | PERSONAL CARE ARTICLE | Reckitt Benckiser Healthcare (UK) Limited (GB) | 2009-01-07 | — | — | EP | claimed |
| US-20090004128-A1 | Non-Irritant Rapid-Action Dipilatory Composition | PRODUCCIONES INFOVISION (MX) | 2009-01-01 | — | — | US | claimed |
| WO-2008155507-A1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-12-24 | — | — | WO | claimed |
| US-20080260671-A1 | Depilatory Compositions | RECKITT BENCKISER (UK) LIMITED (GB) | 2008-10-23 | — | — | US | claimed |
| WO-2007128983-A1 | PERSONAL CARE ARTICLE | RECKITT BENCKISER (UK) LIMITED (GB) | 2007-11-15 | — | — | WO | claimed |
| EP-1001735-B1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT BENCKISER FRANCE (FR) | 2003-03-19 | — | — | EP | claimed |
| US-6306380-B1 | FOR REMOVING UNWANTED BODY HAIR | RECKITT & COLMAN FRANCE (FR) | 2001-10-23 | — | — | US | claimed |
| EP-1001735-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | Reckitt & Colman France (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999002125-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT & COLMAN FRANCE (FR) | 1999-01-21 | — | — | WO | claimed |
| EP-2879762-B1 | NOVEL DEPILATORY PRODUCT | RECKITT & COLMAN OVERSEAS HEALTH LTD (GB) | 2019-11-20 | — | — | EP | disclosed |
| EP-3348250-A1 | DEPILATORY COMPOSITION | Reckitt & Colman (Overseas) Limited (GB) | 2018-07-18 | — | — | EP | disclosed |
| EP-2844351-B1 | NOVEL DEPILATORY COMPOSITIONS | RECKITT & COLMAN OVERSEAS (GB) | 2018-05-23 | — | — | EP | disclosed |
| US-9974735-B2 | Depilatory compositions | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2018-05-22 | — | — | US | disclosed |
| US-9795558-B2 | Depilatory formulations and methods of using same | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2017-10-24 | — | — | US | disclosed |
| US-20170224610-A1 | Depilatory Compositions | RECKITT & COLMAN (OVERSEAS) HEALTH LIMITED (GB) | 2017-08-10 | — | — | US | disclosed |
| US-9573001-B2 | Depilatory composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2017-02-21 | — | — | US | disclosed |
| EP-2155808-B1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | ESSILOR INT (COMPAGNIE GÉNÉRALE D'OPTIQUE) (FR) | 2016-12-14 | — | — | EP | disclosed |
| US-9205037-B2 | Single phase depilatory composition | CHURCH & DWIGHT CO., INC. (US) | 2015-12-08 | — | — | US | disclosed |
| US-9110223-B2 | Method for treating the surface of a substrate based on sulphur polymer, intended to be covered with a coating | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2015-08-18 | — | — | US | disclosed |
| US-20150202140-A1 | Depilatory Formulations And Methods Of Using Same | RECKITT & COLMAN (OVERSEAS) HEALTH LIMITED (GB) | 2015-07-23 | — | — | US | disclosed |
| EP-2879762-A1 | NOVEL DEPILATORY PRODUCT | Reckitt & Colman (Overseas) Limited (GB) | 2015-06-10 | — | — | EP | disclosed |
| US-20150113741-A1 | HAIR REMOVAL COMPOSITIONS | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2015-04-30 | — | — | US | disclosed |
| US-20150074923-A1 | DEPILATORY COMPOSITIONS | RECKITT & COLEMAN (OVERSEAS) LIMITED (GB) | 2015-03-19 | — | — | US | disclosed |
| EP-2844351-A2 | NOVEL DEPILATORY COMPOSITIONS | Reckitt & Colman (Overseas) Limited (GB) | 2015-03-11 | — | — | EP | disclosed |
| US-20140215726-A1 | DEPILATORY COMPOSITIONS | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2014-08-07 | — | — | US | disclosed |
| US-20140170246-A1 | Topical Composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2014-06-19 | — | — | US | disclosed |
| WO-2014080015-A2 | HAIR GROWTH COMPOSITIONS AND METHODS | PILOSCIENCES (FR) | 2014-05-30 | — | — | WO | disclosed |
| EP-2735303-A1 | Hair growth compositions and methods | Pilosciences (FR) | 2014-05-28 | — | — | EP | disclosed |
| US-8709098-B2 | Depilatory composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2014-04-29 | — | — | US | disclosed |
| US-8658222-B2 | Topical composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2014-02-25 | — | — | US | disclosed |
| WO-2014020352-A1 | NOVEL DEPILATORY PRODUCT | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2014-02-06 | — | — | WO | disclosed |
| WO-2013160689-A2 | NOVEL DEPILATORY COMPOSITIONS | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2013-10-31 | — | — | WO | disclosed |
| US-8524207-B2 | Cosmetic compositions | RECKITT BENCKISER (UK) LIMITED (GB) | 2013-09-03 | — | — | US | disclosed |
| US-20130022568-A1 | SINGLE PHASE DEPILATORY COMPOSITION | CHURCH & DWIGHT CO., INC. (US) | 2013-01-24 | — | — | US | disclosed |
| US-20120052035-A1 | Two Phase Depilatory Composition | CHURCH & DWIGHT CO., INC. | 2012-03-01 | — | — | US | disclosed |
| EP-2387441-A2 | TOPICAL COMPOSITION | Reckitt & Colman (Overseas) Limited (GB) | 2011-11-23 | — | — | EP | disclosed |
| US-8040465-B2 | External light illumination of display screens | APPLE INC. (US) | 2011-10-18 | — | — | US | disclosed |
| EP-2355788-A2 | DEPILATORY COMPOSITION | Reckitt & Colman (Overseas) Limited (GB) | 2011-08-17 | — | — | EP | disclosed |
| US-20100189889-A1 | Method for Treating the Surface of a Substrate Based on Sulphur Polymer, Intended to be Covered with a Coating | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2010-07-29 | — | — | US | disclosed |
| WO-2010082024-A2 | TOPICAL COMPOSITION | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010064017-A2 | DEPILATORY COMPOSITION | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2010-06-10 | — | — | WO | disclosed |
| US-20100083443-A1 | Depilatory Composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| EP-2155808-A1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | Essilor International (Compagnie Générale D'Optique) (FR) | 2010-02-24 | — | — | EP | disclosed |
| US-20100028392-A1 | Personal Care Article | RECKITT BENCKISER (UK) LIMITED (GB) | 2010-02-04 | — | — | US | disclosed |
| EP-2120848-A2 | DEPILATORY COMPOSITION | Reckitt Benckiser (UK) Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| US-20090158595-A1 | Microemulsion and Shaving Apparatus Comprising a Microemulsion | RECKITT BENCKISER (UK) LIMITED (GB) | 2009-06-25 | — | — | US | disclosed |
| US-20090117068-A1 | COSMETIC COMPOSITIONS | RECKITT & BENCKISER (UK) LIMITED (GB) | 2009-05-07 | — | — | US | disclosed |
| EP-2010128-A1 | PERSONAL CARE ARTICLE | Reckitt Benckiser Healthcare (UK) Limited (GB) | 2009-01-07 | — | — | EP | disclosed |
| US-20090004128-A1 | Non-Irritant Rapid-Action Dipilatory Composition | PRODUCCIONES INFOVISION (MX) | 2009-01-01 | — | — | US | disclosed |
| WO-2008155507-A1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008110745-A2 | DEPILATORY COMPOSITION | RECKITT BENCKISER (UK) LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| EP-1948121-A1 | MICROEMULSION AND SHAVING APPARATUS COMPRISING A MICROEMULSION | Reckitt Benckiser (UK) LIMITED (GB) | 2008-07-30 | — | — | EP | disclosed |
| EP-1937364-A2 | IMPROVEMENTS IN OR RELATIMG TO COSMETIC COMPOSITIONS | Reckitt Benckiser (UK) Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007128983-A1 | PERSONAL CARE ARTICLE | RECKITT BENCKISER (UK) LIMITED (GB) | 2007-11-15 | — | — | WO | disclosed |
| US-20070248563-A1 | Skin care compositions including marine extracts | GILLETTE COMPANY, THE | 2007-10-25 | — | — | US | disclosed |
| WO-2007119227-A2 | SKIN CARE COMPOSITIONS INCLUDING MARINE EXTRACTS | THE GILLETTE COMPANY (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007042824-A1 | MICROEMULSION AND SHAVING APPARATUS COMPRISING A MICROEMULSION | RECKITT BENCKISER (UK) LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007031793-A2 | IMPROVEMENTS IN OR RELATIMG TO COSMETIC COMPOSITIONS | RECKITT BENCKISER (UK) LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |
| EP-1660187-A1 | METHOD AND KIT FOR REDUCING IRRITATION OF SKIN DELIPATORY COMPOSITIONS | UNILEVER PLC (GB) | 2006-05-31 | — | — | EP | disclosed |
| US-20060002878-A1 | Cosmetic article and related methods | RECKITT BENCKISER (UK) LIMITED (GB) | 2006-01-05 | — | — | US | disclosed |
| EP-1551250-A1 | COSMETIC ARTICLE AND RELATED METHODS | Reckitt Benckiser (UK) LIMITED (GB) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004096164-A1 | METHOD AND KIT FOR REDUCING IRRITATION OF SKIN DELIPATORY COMPOSITIONS | UNILEVER PLC (GB) | 2004-11-11 | — | — | WO | disclosed |
| US-20040219118-A1 | Method and kit for reducing irritation of skin depilatory compositions | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-11-04 | — | — | US | disclosed |
| WO-2004014179-A1 | COSMETIC ARTICLE AND RELATED METHODS | RECKITT BENCKISER (UK) LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |
| EP-1001735-B1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT BENCKISER FRANCE (FR) | 2003-03-19 | — | — | EP | disclosed |
| US-6306380-B1 | FOR REMOVING UNWANTED BODY HAIR | RECKITT & COLMAN FRANCE (FR) | 2001-10-23 | — | — | US | disclosed |
| EP-1001735-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | Reckitt & Colman France (FR) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999002125-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT & COLMAN FRANCE (FR) | 1999-01-21 | — | — | WO | disclosed |
| WO-1999002125-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT & COLMAN FRANCE (FR) | 1999-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080260671-A1 | Depilatory Compositions | TYR, NQO1, COMT | CA1 3338/4885FABP3 2320/4885HDAC3 517/4885 |
| US-20120052035-A1 | Two Phase Depilatory Composition | DEPTOR, PARG, PARN | CA1 3364/4885FABP3 4371/4885HDAC3 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.