Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.62 |
| ▸ | MMP13 | P45452 | 6/20 | 0.62 |
| ▸ | MMP3 | P08254 | 3/20 | 0.62 |
| ▸ | MMP8 | P22894 | 2/20 | 0.62 |
| ▸ | MMP2 | P08253 | 5/20 | 0.56 |
| ▸ | MMP14 | P50281 | 3/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.56 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1785001 | 0.84 | PSIP1 (0.52) | MMP1MMP13MMP3MMP8LMNA | |
| SCHEMBL7207056 | 0.79 | MMP13 (0.60) | MMP1MMP13MMP8HTTALDH1A1 | |
| Diphenylether SCHEMBL5161616 | 0.78 | LTA4H (0.60) | SOS1LMNAGAAKMT2ACA1 | |
| SCHEMBL7208687 | 0.77 | MMP13 (1.00) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL7212133 | 0.77 | MMP1 (0.71) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL8189068 | 0.74 | MMP1 (0.69) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL7924711 | 0.73 | MMP2 (0.63) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL5974473 | 0.73 | ALDH1A1 (0.64) | LMNAALDH1A1MEN1GAAKMT2A | |
| SCHEMBL30765734 | 0.72 | FFAR1 (0.54) | MMP13FFAR1 | |
| SCHEMBL4294057 | 0.72 | MMP1 (0.56) | MMP1MMP13MMP3MMP8MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0939628-A4 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0939628-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003164-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |