Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313917 | 0.98 | SIGMAR1 (0.34) | SIGMAR1MAPK1L3MBTL1HRH2HRH1 | |
| SCHEMBL7313718 | 0.95 | SIGMAR1 (0.31) | SIGMAR1MAPK1L3MBTL1 | |
| SCHEMBL7313885 | 0.89 | GPR119 (0.38) | MAPK1L3MBTL1 | |
| SCHEMBL7307684 | 0.88 | GPR119 (0.39) | MAPK1L3MBTL1 | |
| SCHEMBL7314189 | 0.87 | GPR119 (0.33) | — | |
| SCHEMBL7227670 | 0.86 | CHRM2 (0.41) | MAPK1L3MBTL1CHRM2CHRM1STAT3 | |
| SCHEMBL7228352 | 0.85 | CHRM2 (0.41) | MAPK1L3MBTL1CHRM2CHRM1STAT3 | |
| SCHEMBL7307739 | 0.83 | SIGMAR1 (0.35) | SIGMAR1MAPK1L3MBTL1HRH2HRH1 | |
| SCHEMBL7309520 | 0.83 | SIGMAR1 (0.36) | SIGMAR1MAPK1L3MBTL1HRH2HRH1 | |
| SCHEMBL7309308 | 0.83 | SIGMAR1 (0.36) | SIGMAR1MAPK1L3MBTL1HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776937-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-07-07 | — | — | US | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |
| EP-0711770-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-15 | — | — | EP | disclosed |