SCHEMBL724619

SCHEMBL724619

OCCC(c1ccccc1)c1cc(Br)ccc1OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
USP28 Q96RU2 1/20 0.52
USP25 Q9UHP3 1/20 0.52
HTT P42858 2/20 0.51
ALDH1A1 P00352 3/20 0.48
CCR5 P51681 5/20 0.47
RAB9A P51151 1/20 0.46
LMNA P02545 2/20 0.46
SLC6A4 P31645 1/20 0.44
HTR7 P34969 1/20 0.44
HTR6 P50406 1/20 0.44
MAOB P27338 1/20 0.42
USP2 O75604 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PTGER1 P34995 2/20 0.41
LRRK2 Q5S007 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12293723 1.00 USP28 (0.52) USP28USP25HTTALDH1A1CCR5
SCHEMBL9287833 0.88 HTT (0.46) USP28USP25HTTALDH1A1CCR5
SCHEMBL15150708 0.87 CCR5 (0.47) USP28USP25HTTALDH1A1CCR5
SCHEMBL27530657 0.87 CCR5 (0.47) USP28USP25HTTALDH1A1CCR5
SCHEMBL15148414 0.85 CCR5 (0.53) USP28USP25HTTALDH1A1CCR5
SCHEMBL724632 0.85 CCR5 (0.53) USP28USP25HTTALDH1A1CCR5
SCHEMBL12403881 0.85 CCR5 (0.48) USP28USP25HTTALDH1A1CCR5
SCHEMBL4064320 0.84 PTGER1 (0.44) USP28USP25ALDH1A1LMNASLC6A4
SCHEMBL12121777 0.84 PTGER1 (0.44) USP28USP25ALDH1A1LMNASLC6A4
SCHEMBL12856629 0.84 CFD (0.39) USP28USP25HTTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012678-B2 Processes for the preparation of fesoterodine CADILA HEALTHCARE LIMITED (IN) 2015-04-21 US claimed
US-20130197260-A1 PROCESSES FOR THE PREPARATION OF FESOTERODINE CADILA HEALTHCARE LIMITED (IN) 2013-08-01 US claimed
WO-2012098560-A2 PROCESS FOR THE PREPARATION OF MUSCARINIC RECEPTOR ANTAGONIST MSN LABORATORIES LIMITED (IN) 2012-07-26 WO claimed
WO-2012025941-A2 PROCESSES FOR THE PREPARATION OF FESOTERODINE CADILA HEALTHCARE LIMITED (IN) 2012-03-01 WO claimed
EP-2855421-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 3,3-DIPHENYLPROPYLAMINES CRYSTAL PHARMA SAU (ES) 2018-03-21 EP disclosed
US-9422228-B2 Process for the preparation of optically pure fesoterodine derivatives CRYSTAL PHARMA, S.A.U. (ES) 2016-08-23 US disclosed
US-9422228-B2 Process for the preparation of optically pure fesoterodine derivatives CRYSTAL PHARMA, S.A.U. (ES) 2016-08-23 US disclosed
US-9012678-B2 Processes for the preparation of fesoterodine CADILA HEALTHCARE LIMITED (IN) 2015-04-21 US disclosed
US-9012678-B2 Processes for the preparation of fesoterodine CADILA HEALTHCARE LIMITED (IN) 2015-04-21 US disclosed
US-9012678-B2 Processes for the preparation of fesoterodine CADILA HEALTHCARE LIMITED (IN) 2015-04-21 US disclosed
US-20150094485-A1 PROCESS FOR THE PREPARATION OF OPTICALLY PURE FESOTERODINE DERIVATIVES CURIA SPAIN, S.A.U. (ES) 2015-04-02 US disclosed
US-20150094485-A1 PROCESS FOR THE PREPARATION OF OPTICALLY PURE FESOTERODINE DERIVATIVES CURIA SPAIN, S.A.U. (ES) 2015-04-02 US disclosed
EP-0957073-A1 Novel derivatives of 3,3-diphenylpropylamines SCHWARZ PHARMA AG (DE) 1999-11-17 EP disclosed
WO-1998043942-A1 NOVEL COMPOUNDS, THEIR USE AND PREPARATION PHARMACIA & UPJOHN AB (SE) 1998-10-08 WO disclosed
EP-0667852-B1 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION PHARMACIA & UPJOHN AB (SE) 1998-04-08 EP disclosed
US-5686464-A ANTICHOLINERGIC AGENTS; URINARY INCONTINENCE TREATMENT PHARMACIA AB (SE) 1997-11-11 US disclosed
US-5559269-A ANTICHOLINERGIC AGENTS PHARMACIA AB (SE) 1996-09-24 US disclosed
EP-0667852-A1 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION Pharmacia & Upjohn Aktiebolag (SE) 1995-08-23 EP disclosed
WO-1994011337-A9 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION 1995-07-06 WO disclosed
WO-1994011337-A1 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION PHARMACIA AB (SE) 1994-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130197260-A1 PROCESSES FOR THE PREPARATION OF FESOTERODINE QDPR, FES, SULT1A1 USP28 2048/4885USP25 1260/4885HTT 1119/4885
US-20150094485-A1 PROCESS FOR THE PREPARATION OF OPTICALLY PURE FESOTERODINE DERIVATIVES ADH1C, NISCH, ADH1A USP28 3945/4885USP25 3957/4885HTT 1713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.