Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257809 | 0.78 | MAPK1 (0.49) | ALDH1A1KDM4EPOLBMAOBXDH | |
| SCHEMBL25387499 | 0.77 | XDH (0.47) | MAOBXDHSGMS2LMNASQOR | |
| SCHEMBL1921249 | 0.77 | MAOB (0.53) | ALDH1A1KDM4EPOLBMAOBXDH | |
| SCHEMBL12985052 | 0.76 | GCK (0.48) | ALDH1A1MAOBXDHMAPTL3MBTL1 | |
| SCHEMBL20607927 | 0.76 | GCK (0.46) | MAOBXDHMAPK14SQORSMN1; SMN2 | |
| SCHEMBL18865570 | 0.76 | PLAU (0.54) | MAOBXDHSGMS2PLAUNPC1 | |
| SCHEMBL7238321 | 0.76 | HTR1A (0.46) | MAPTL3MBTL1MAPK1TDP1LTA4H | |
| SCHEMBL26534330 | 0.76 | L3MBTL1 (0.53) | MAPTL3MBTL1MAPK1TDP1LTA4H | |
| SCHEMBL10822615 | 0.74 | MAOB (0.59) | MAOBXDHMAPTL3MBTL1SGMS2 | |
| SCHEMBL4214379 | 0.74 | LTA4H (0.58) | ALDH1A1MAOBMAPTL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528649-B2 | Central nervous system disorders | NEUROGEN CORPORATION | 2003-03-04 | — | — | US | disclosed |
| US-20020019410-A1 | Imidazoloisoquinolines | NEUROGEN CORPORATION | 2002-02-14 | — | — | US | disclosed |
| WO-2001092258-A1 | IMIDAZOLOISOQUINOLINES | NEUROGEN CORPORATION (US) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019410-A1 | Imidazoloisoquinolines | GABRP, GABRA2, GABRA3 | ALDH1A1 911/4885KDM4E 3160/4885POLB 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.