Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663530 | 0.84 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL7247948 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL7664079 | 0.80 | ATM (0.53) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL7673427 | 0.76 | CCR2 (0.52) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6927266 | 0.75 | C1S (0.63) | — | |
| SCHEMBL7248655 | 0.75 | SLC40A1 (0.45) | ALDH1A1SLC40A1EDNRAKDM1AMAOA | |
| SCHEMBL7241182 | 0.74 | HTR2A (0.41) | ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL13230136 | 0.72 | PKM (0.60) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL28636424 | 0.72 | KMT2A (0.65) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL7588947 | 0.72 | KMT2A (0.57) | ALDH1A1KMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562840-B1 | Non-peptidic inhibitors of proteolytic enzymes such as urokinase | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-05-13 | — | — | US | disclosed |
| US-6492403-B1 | TREATING SYMPTOMS OF ACUTE OR CHRONIC DISORDER MEDIATED BY CLASSICAL PATHWAY OF COMPLEMENT CASCADE; PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |