SCHEMBL728053

SCHEMBL728053

CCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
THRB P10828 1/20 0.35
ADRB2 P07550 1/20 0.32
ADRB1 P08588 1/20 0.32
ADRB3 P13945 1/20 0.32
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1959828 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL4774885 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL727830 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL20477180 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL21114738 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL5711705 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL727806 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL1915388 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL11926993 0.97 TSHR (0.40) TSHRTHRBLMNA
SCHEMBL14270566 0.97 TSHR (0.40) TSHRTHRBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112915047-B Anti-migration lip nourishing glaze 浙江亦轩化妆品有限公司 2022-08-26 CN claimed
CN-112915047-A Anti-migration lip nourishing glaze 浙江亦轩化妆品有限公司 2021-06-08 CN claimed
CN-101360476-B Swollen silicone composition, method of making, and article thereof MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-08-05 CN claimed
JP-2011527341-A 2011-10-27 JP claimed
US-8017687-B2 Swollen silicone composition and process of producing same MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-09-13 US claimed
EP-2296667-A2 SILICONE COMPOSITION Momentive Performance Materials Inc. (US) 2011-03-23 EP claimed
EP-2228053-A1 Swollen silicone composition and process of producing same Momentive Performance Materials Inc. (US) 2010-09-15 EP claimed
JP-2010515566-A 2010-05-13 JP claimed
WO-2010005538-A2 SILICONE COMPOSITION MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2010-01-14 WO claimed
US-20100003201-A1 Silicone composition MOMENTIVE PERFORMANCE MATERIALS, INC. 2010-01-07 US claimed
EP-2108028-A2 METHOD OF APPLYING A COMPOSITION Momentive Performance Materials Inc. (US) 2009-10-14 EP claimed
JP-2009516024-A 2009-04-16 JP claimed
EP-1968533-A1 SWOLLEN SILICONE COMPOSITION AND PROCESS OF PRODUCING SAME Momentive Performance Materials Inc. (US) 2008-09-17 EP claimed
EP-1962791-A1 SWOLLEN SILICONE COMPOSITION, PROCESS OF PRODUCING SAME AND PRODUCTS THEREOF Momentive Performance Materials Inc. (US) 2008-09-03 EP claimed
WO-2008088323-A2 METHOD OF APPLYING A COMPOSITION MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-07-24 WO claimed
US-20070160547-A1 Method of applying a composition MOMENTIVE PERFORMANCE MATERIALS INC. 2007-07-12 US claimed
WO-2007061623-A1 SWOLLEN SILICONE COMPOSITION, PROCESS OF PRODUCING SAME AND PRODUCTS THEREOF MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-05-31 WO claimed
WO-2007058825-A1 SWOLLEN SILICONE COMPOSITION AND PROCESS OF PRODUCING SAME MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-05-24 WO claimed
US-20070112146-A1 Swollen silicone composition, process of producing same and products thereof MOMENTIVE PERFORMANCE MATERIALS INC. 2007-05-17 US claimed
US-20070112112-A1 Swollen silicone composition and process of producing same MOMENTIVE PERFORMANCE MATERIALS INC. 2007-05-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100003201-A1 Silicone composition CUTA, SMURF1, MMS19 TSHR 3819/4885THRB 3235/4885ADRB2 4812/4885
US-20070112146-A1 Swollen silicone composition, process of producing same and products thereof PIEZO1, SMS, ALG3 TSHR 4427/4885THRB 4562/4885ADRB2 4610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.