Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 5/20 | 0.83 |
| ▸ | ABL1 | P00519 | 1/20 | 0.83 |
| ▸ | IKBKB | O14920 | 3/20 | 0.77 |
| ▸ | CHUK | O15111 | 3/20 | 0.77 |
| ▸ | IKBKG | Q9Y6K9 | 3/20 | 0.77 |
| ▸ | SNCA | P37840 | 4/20 | 0.76 |
| ▸ | BACE1 | P56817 | 2/20 | 0.62 |
| ▸ | AKT1 | P31749 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.59 |
| ▸ | STAT3 | P40763 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.59 |
| ▸ | APP | P05067 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23817770 | 0.87 | GLO1 (1.00) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL29449976 | 0.87 | GLO1 (1.00) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL7585369 | 0.85 | GLO1 (0.87) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL30497483 | 0.85 | GLO1 (0.87) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL3200679 | 0.84 | BACE1 (0.88) | GLO1SNCABACE1NFKB1CYP2D6 | |
| SCHEMBL3200665 | 0.84 | BACE1 (0.88) | GLO1SNCABACE1NFKB1CYP2D6 | |
| SCHEMBL16153678 | 0.81 | GLO1 (0.55) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL16153677 | 0.81 | GLO1 (0.54) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL11933618 | 0.80 | GLO1 (0.86) | GLO1ABL1IKBKBCHUKIKBKG | |
| SCHEMBL4463365 | 0.79 | SNCA (0.79) | GLO1ABL1IKBKBCHUKIKBKG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844012-B2 | Antibacterial compounds and methods of use thereof | WAYNE STATE UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200283384-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | WAYNE STATE UNIVERSITY (US) | 2020-09-10 | — | — | US | disclosed |
| US-10703716-B2 | Antibacterial compounds and methods of use thereof | WAYNE STATE UNIVERSITY (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190031610-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | WAYNE STATE UNIVERSITY (US) | 2019-01-31 | — | — | US | disclosed |
| WO-2017161374-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | WAYNE STATE UNIVERSITY (US) | 2017-09-21 | — | — | WO | disclosed |
| US-20140303109-A1 | Novel Analogs of Curcumin and Methods of Use | SARKAR FAZLUL H (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140303109-A1 | Novel Analogs of Curcumin and Methods of Use | SARKAR FAZLUL H (US) | 2014-10-09 | — | — | US | disclosed |
| WO-2011142795-A9 | NOVEL ANALOGS OF CURCUMIN AND METHODS OF USE | WAYNE STATE UNIVERSITY (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011142795-A1 | NOVEL ANALOGS OF CURCUMIN AND METHODS OF USE | WAYNE STATE UNIVERSITY (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303109-A1 | Novel Analogs of Curcumin and Methods of Use | KLHL6, KEAP1, SOD1 | GLO1 1364/4885ABL1 3353/4885IKBKB 15/4885 |
| US-10703716-B2 | Antibacterial compounds and methods of use thereof | CLPP, MMP8, MPO | GLO1 1029/4885ABL1 358/4885IKBKB 1812/4885 |
| US-10844012-B2 | Antibacterial compounds and methods of use thereof | CLPP, MMP8, MPO | GLO1 1029/4885ABL1 358/4885IKBKB 1812/4885 |
| US-20190031610-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | CLPP, MMP8, MPO | GLO1 1029/4885ABL1 358/4885IKBKB 1812/4885 |
| US-20200283384-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | CLPP, MMP8, MPO | GLO1 1029/4885ABL1 358/4885IKBKB 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.