SCHEMBL730049

SCHEMBL730049

COc1ccc2ncccc2c1C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA7 P43166 1/20 0.51
CA9 Q16790 1/20 0.51
CA14 Q9ULX7 1/20 0.51
FABP5 Q01469 1/20 0.47
CDC25B P30305 2/20 0.47
MAPT P10636 3/20 0.46
KDM4E B2RXH2 2/20 0.46
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
HSD17B10 Q99714 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
ERN1 O75460 1/20 0.44
ALOX15 P16050 1/20 0.44
SYK P43405 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
MEN1 O00255 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30744813 0.84 KDM4E (0.42) FABP5MAPTKDM4ELMNAERN1
SCHEMBL8655678 0.82 CTSA (0.43)
SCHEMBL7638168 0.79 ALOX15 (0.53) CA12CA1CA2CA7CA9
SCHEMBL69562 0.77 KDM4E (0.52) MAPTKDM4ELMNASMN1; SMN2L3MBTL1
SCHEMBL29415433 0.77 KDM4E (0.52) MAPTKDM4ELMNASMN1; SMN2L3MBTL1
SCHEMBL729995 0.77 ERN1 (0.56) CA12CA1CA2CA7CA9
SCHEMBL980430 0.77 CA12 (0.69) CA12CA1CA2CA7CA9
SCHEMBL14888067 0.76 KDM4E (0.50) MAPTKDM4ELMNAL3MBTL1ERN1
SCHEMBL1134041 0.76 P2RX7 (0.53) MAPTKDM4ELMNASMN1; SMN2L3MBTL1
SCHEMBL3986493 0.76 MEN1 (0.58) FABP5MAPTKDM4ELMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111295382-B Bridged bicyclic compounds as farnesyl ester X receptor modulators 百时美施贵宝公司 2024-02-02 CN claimed
US-20180064667-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LTD (IE) 2018-03-08 US claimed
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LIMITED (IE) 2015-03-26 US claimed
EP-2844242-A1 METHODS OF TREATING LACTOSE INTOLERANCE Nogra Pharma Limited (IE) 2015-03-11 EP claimed
CN-104284655-A Methods of treating lactose intolerance NOGRA PHARMA LTD 2015-01-14 CN claimed
WO-2013156413-A1 METHODS OF TREATING LACTOSE INTOLERANCE NOGRA PHARMA LIMITED (IE) 2013-10-24 WO claimed
US-8450506-B2 Compounds and their salts specific to the PPAR receptors and the EGF Receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2013-05-28 US claimed
US-20120316230-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2012-12-13 US claimed
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants NOGRA PHARMA LIMITED (IE) 2011-06-23 US claimed
CN-101969943-A Compounds for the selective treatment of the intestinal immunoinflammatory component of celiac disease GIULIANI INT LTD 2011-02-09 CN claimed
US-20100305077-A1 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE NOGRA PHARMA LIMITED (IE) 2010-12-02 US claimed
EP-2131829-A1 PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS Giuliani International Limited (IE) 2009-12-16 EP claimed
US-20090118357-A1 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field GIULIANI INTERNATIONAL LIMITED (IE) 2009-05-07 US claimed
WO-2008104557-A1 PPAR-GAMMA AGONISTS FOR THE INDUCTION OF CATIONIC ANTIMICROBIAL PEPTIDE EXPRESSION AS IMMUNOPROTECTIVE STIMULANTS GIULIANI INTERNATIONAL LIMITED (IE) 2008-09-04 WO claimed
CN-101243043-A Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field GIULIANI INT LTD (IE) 2008-08-13 CN claimed
US-12291494-B2 Methods of treating fibrosis NOGRA PHARMA LIMITED (IE) 2025-05-06 US disclosed
US-20240279157-A1 METHODS OF TREATING FIBROSIS NOGRA PHARMA LIMITED (IE) 2024-08-22 US disclosed
CN-101243043-A Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field GIULIANI INT LTD (IE) 2008-08-13 CN disclosed
EP-1910275-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD Giuliani International Limited (IE) 2008-04-16 EP disclosed
WO-2007010514-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118357-A1 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field EGFR, ERBB3, FGFR3 CA12 3767/4885CA1 4260/4885CA2 2353/4885
US-20100305077-A1 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE SI, FABP2, NFKBIA CA12 226/4885CA1 517/4885CA2 369/4885
US-20240279157-A1 METHODS OF TREATING FIBROSIS MMP1, MMP8, FABP2 CA12 2122/4885CA1 4002/4885CA2 3469/4885
US-20150087678-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG CA12 2124/4885CA1 3821/4885CA2 2310/4885
US-20120316230-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 CA12 3635/4885CA1 4145/4885CA2 1987/4885
US-12291494-B2 Methods of treating fibrosis MMP1, MMP8, FABP2 CA12 2122/4885CA1 4002/4885CA2 3469/4885
US-20180064667-A1 METHODS OF TREATING LACTOSE INTOLERANCE LCT, LPL, PPARG CA12 2124/4885CA1 3821/4885CA2 2310/4885
US-20110152225-A1 PPAR-Gamma Agonists for the Induction of Cationic Antimicrobial Peptide Expression as Immunoprotective Stimulants PPARG, FABP2, PPARD CA12 4780/4885CA1 4514/4885CA2 4139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.