Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308372 | 0.85 | AR (0.57) | MAPTNPSR1LMNAHSD17B10HTR1A | |
| SCHEMBL7297432 | 0.83 | HTR7 (0.74) | PARP1HTR7HTR1A | |
| SCHEMBL7303413 | 0.82 | MAPT (0.49) | MAPTNPSR1LMNAHSD17B10HTR1A | |
| SCHEMBL7301705 | 0.81 | LMNA (0.61) | MAPTNPSR1LMNAKDM4EHSD17B10 | |
| SCHEMBL7300140 | 0.80 | FABP4 (0.68) | PARP1KDM4EHSD17B10HTR1AALDH1A1 | |
| SCHEMBL30427936 | 0.75 | PARP1 (0.59) | MAPTNPSR1LMNAPARP1KDM4E | |
| SCHEMBL12822508 | 0.75 | PARP1 (0.59) | MAPTNPSR1LMNAPARP1KDM4E | |
| SCHEMBL7306335 | 0.75 | HSD17B10 (0.56) | MAPTNPSR1LMNAPARP1KDM4E | |
| SCHEMBL13799882 | 0.74 | FABP4 (0.66) | MAPTPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL7298835 | 0.74 | KDM4E (0.53) | MAPTNPSR1PARP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |