Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ESR1 | P03372 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303729 | 0.85 | HTR1A (0.64) | HTR1ADRD2HTR2A | |
| SCHEMBL7308372 | 0.85 | AR (0.57) | MAPTESR1HTR1ADRD2HTR2A | |
| SCHEMBL7302783 | 0.82 | MAPT (0.70) | MAPTESR1HTR1AALDH1A1SMN1; SMN2 | |
| SCHEMBL7301705 | 0.81 | LMNA (0.61) | MAPTHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL7300140 | 0.71 | FABP4 (0.68) | HTR1ADRD2HTR2AALDH1A1TSHR | |
| SCHEMBL7306583 | 0.70 | HTR1A (0.70) | HTR1ADRD2HTR2ALMNA | |
| SCHEMBL3210388 | 0.70 | DRD2 (0.59) | MAPTHTR1ADRD2HTR2ALMNA | |
| SCHEMBL7306335 | 0.69 | HSD17B10 (0.56) | MAPTALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL11785627 | 0.69 | PARP1 (0.49) | MAPTALDH1A1LMNA | |
| SCHEMBL7297796 | 0.69 | HTR1A (0.68) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |