Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | FDPS | P14324 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311695 | 0.84 | HSD11B1 (0.38) | HSD11B1MMP2MMP13MMP1PPARG | |
| SCHEMBL7315311 | 0.78 | MAPT (0.43) | HSD11B1KMT2AMAPTALDH1A1 | |
| SCHEMBL7301814 | 0.72 | KMT2A (0.40) | HSD11B1MMP2MMP13KMT2AMEN1 | |
| SCHEMBL7479619 | 0.70 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL7310826 | 0.69 | MMP3 (0.52) | MMP13KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL7478269 | 0.68 | MMP3 (0.57) | KMT2AMEN1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11373498 | 0.68 | PPARG (0.40) | KMT2AMEN1PPARGSMN1; SMN2MAPT | |
| SCHEMBL7306332 | 0.67 | CYP2C19 (0.41) | HSD11B1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL9504834 | 0.66 | KCNN4 (0.41) | MMP2MMP13KMT2AMEN1PPARG | |
| SCHEMBL6245112 | 0.66 | ALDH1A1 (0.42) | KMT2AMEN1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |