Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 5/20 | 0.39 |
| ▸ | MMP12 | P39900 | 5/20 | 0.39 |
| ▸ | MMP8 | P22894 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | MMP14 | P50281 | 4/20 | 0.39 |
| ▸ | MMP16 | P51512 | 4/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311850 | 0.94 | KDM4E (0.42) | SMN1; SMN2POLBMMP2MMP12MMP8 | |
| SCHEMBL7322248 | 0.92 | MMP13 (0.43) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7324047 | 0.92 | GABRG2 (0.42) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7317430 | 0.90 | MMP9 (0.44) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7322262 | 0.88 | LMNA (0.43) | SMN1; SMN2MMP2MMP12MMP8MMP13 | |
| SCHEMBL7320912 | 0.86 | THRB (0.41) | POLBMMP2MMP12MMP8MMP13 | |
| SCHEMBL7320885 | 0.86 | MMP1 (0.44) | MMP13MMP9MMP1ADAM17KDM4E | |
| SCHEMBL7316602 | 0.85 | MMP13 (0.43) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7321948 | 0.85 | MMP9 (0.41) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7321871 | 0.85 | MAPT (0.37) | SMN1; SMN2POLBMMP2MMP12MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |