Sugi Predict

Sugi Predict / Compounds / SCHEMBL73493

SCHEMBL73493

SCHEMBL73493

CC(C)(C)OC(=O)N1CCC(c2ccccc2N)CC1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 6/20 0.55
▸ NAMPT P43490 1/20 0.52
▸ KDM4E B2RXH2 2/20 0.51
▸ THRB P10828 2/20 0.51
▸ MAPT P10636 1/20 0.51
▸ PKM P14618 1/20 0.50
▸ PTPN2 P17706 1/20 0.48
▸ PTPN1 P18031 1/20 0.48
▸ PTPN6 P29350 1/20 0.48
▸ HPGDS O60760 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ STS P08842 1/20 0.47
▸ PDE10A Q9Y233 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30534946 1.00 GPR119 (0.55) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL2078377 0.92 GPR119 (0.50) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL4079483 0.90 GPR119 (0.50) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL24793975 0.88 GPR119 (0.49) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL30431475 0.88 GPR119 (0.49) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL30896744 0.87 STS (0.50) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL31605690 0.87 STS (0.50) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL30193098 0.87 ALOX5AP (0.48) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL3436365 0.86 GPR119 (0.58) GPR119NAMPTKDM4ETHRBMAPT
SCHEMBL21953943 0.85 GPR119 (0.56) GPR119NAMPTKDM4ETHRBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9045422-B2 Piperidine derivatives with pesticidal properties SYNGENTA PARTICIPATIONS AG (CH) 2015-06-02 — — US claimed
US-20130310399-A1 CHEMICAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-11-21 — — US claimed
US-20120270885-A1 CHEMICAL COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2012-10-25 — — US claimed
US-8129534-B2 Chemical compounds SYNGENTA CROP PROTECTION, INC. (US) 2012-03-06 — — US claimed
US-20090042938-A1 Chemical Compounds SYNGENTA CROP PROTECTION, INC. (US) 2009-02-12 — — US claimed
EP-1763302-A2 CHEMICAL COMPOUNDS Syngeta Participations AG (CH) 2007-03-21 — — EP claimed
WO-2006003494-A2 PIPERIDINE DERIVATIVES AND THEIR USE AS INSECTICIDES, ACARICIDES, MOLLUSCICIDES OR NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2006-01-12 — — WO claimed
US-12466815-B2 Carboxamide compounds and uses thereof INCYTE CORPORATION (US) 2025-11-11 — — US disclosed
US-20240299348-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE CARAWAY THERAPEUTICS, INC. 2024-09-12 — — US disclosed
US-20240150326-A1 CARBOXAMIDE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2024-05-09 — — US disclosed
CN-112292380-B N- (phenyl) -2- (phenyl) pyrimidine-4-carboxamide derivatives and related compounds as HPK1 inhibitors for the treatment of cancer 因赛特公司 2024-04-05 — — CN disclosed
US-11731958-B2 Carboxamide compounds and uses thereof INCYTE CORPORATION (US) 2023-08-22 — — US disclosed
US-11731958-B2 Carboxamide compounds and uses thereof INCYTE CORPORATION (US) 2023-08-22 — — US disclosed
US-6365602-B1 FOR THERAPY OF DEPRESSION, ANXIETY, ASTHMA, PAIN, INFLAMMATION, URINARY INCONTINENCE AND OTHER DISEASE CONDITIONS ASTRA ZENECA AB (SE) 2002-04-02 — — US disclosed
CN-1309638-A N-substituted naphthamides as neurokinin receptor antagonists ASTRAZENECA AB (SE) 2001-08-22 — — CN disclosed
EP-1119551-A1 NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2001-08-01 — — EP disclosed
EP-1097137-A1 N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2001-05-09 — — EP disclosed
WO-2000020389-A1 NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2000-04-13 — — WO disclosed
WO-2000002859-A1 N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2000-01-20 — — WO disclosed
US-5885999-A TREATMENT OR PREVENTION OF PAIN, INFLAMMATION, MIGRAINE, EMESIS AND POSTHERPETIC NEURALGIA MERCK SHARP & DOHME LTD. (GB) 1999-03-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120270885-A1 CHEMICAL COMPOUNDS H1-0, CHRM1, MRM1 GPR119 2861/4885NAMPT 3925/4885KDM4E 1400/4885
US-20090042938-A1 Chemical Compounds CHRM1, MRM1, H1-0 GPR119 3057/4885NAMPT 3771/4885KDM4E 1362/4885
US-11731958-B2 Carboxamide compounds and uses thereof PCK1, PHKG2, PHKG1 GPR119 520/4885NAMPT 697/4885KDM4E 1788/4885
US-20240150326-A1 CARBOXAMIDE COMPOUNDS AND USES THEREOF PCK1, PHKG2, PHKG1 GPR119 520/4885NAMPT 697/4885KDM4E 1788/4885
US-20240299348-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE TRPM5, TRPM6, TRPM2 GPR119 2357/4885NAMPT 2053/4885KDM4E 3791/4885
US-20130310399-A1 CHEMICAL COMPOUNDS ACHE, CHRM1, CHRM2 GPR119 1877/4885NAMPT 4264/4885KDM4E 1168/4885
US-12466815-B2 Carboxamide compounds and uses thereof PCK1, PHKG2, PHKG1 GPR119 520/4885NAMPT 697/4885KDM4E 1788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.