Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353056 | 0.88 | DRD2 (0.46) | DRD2ACKR3HTR1ADRD3 | |
| SCHEMBL7344193 | 0.87 | ALDH1A1 (0.47) | DRD2ACKR3HTR1A | |
| SCHEMBL7351979 | 0.85 | DRD2 (0.44) | DRD2ACKR3HTR1AADRA1AADRA1D | |
| SCHEMBL7352017 | 0.83 | DRD2 (0.44) | DRD2ACKR3HTR1AADRA1BSIGMAR1 | |
| SCHEMBL7352192 | 0.79 | DRD2 (0.62) | DRD2HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL7353482 | 0.78 | DRD2 (0.44) | DRD2ACKR3HTR1AADRA1AADRA1B | |
| SCHEMBL10745051 | 0.74 | DRD2 (0.81) | DRD2HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL7346162 | 0.73 | HTR1A (0.38) | DRD2HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL7353631 | 0.73 | MAPT (0.38) | DRD2ACKR3 | |
| SCHEMBL7353206 | 0.72 | DRD2 (0.46) | DRD2ACKR3HTR1AADRA1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | claimed |
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | disclosed |