Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353206 | 0.88 | DRD2 (0.46) | DRD2HTR1AADRA1AHTR2ADRD3 | |
| SCHEMBL7350783 | 0.87 | ALDH1A1 (0.47) | HTR1ACYP1A2CYP2D6ACKR3 | |
| SCHEMBL7350499 | 0.85 | DRD2 (0.44) | DRD2HTR1AADRA1ADRD3ADRA2A | |
| SCHEMBL7353482 | 0.83 | DRD2 (0.44) | DRD2HTR1AADRA1AHTR2ADRD3 | |
| SCHEMBL7352192 | 0.79 | DRD2 (0.62) | DRD2HTR1AADRA1AHTR2ADRD3 | |
| SCHEMBL7352017 | 0.78 | DRD2 (0.44) | DRD2HTR1ACYP1A2CYP2D6ACKR3 | |
| SCHEMBL7347489 | 0.73 | HTR1A (0.38) | DRD2HTR1AADRA1ADRD3SLC6A4 | |
| SCHEMBL7352747 | 0.73 | ALDH1A1 (0.43) | HTR2AACKR3SIGMAR1 | |
| SCHEMBL7353056 | 0.72 | DRD2 (0.46) | DRD2HTR1ADRD3ACKR3DRD4 | |
| SCHEMBL11548884 | 0.72 | DRD2 (0.61) | DRD2HTR1AADRA1AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | claimed |
| EP-0972764-A1 | Aminoalcohols and aminoketones as CNS active agents | Universita Degli Studi di Firenze (IT) | 2000-01-19 | — | — | EP | disclosed |