Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.49 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 9/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365629 | 0.90 | MMP8 (0.63) | MMP8SRRPSAT1PPARGPPARA | |
| SCHEMBL8719475 | 0.85 | MMP8 (0.58) | MMP8SRRPSAT1PPARGPPARA | |
| SCHEMBL165382 | 0.80 | MMP8 (0.76) | MMP8PPARGPKMALDH1A1TP53 | |
| SCHEMBL467987 | 0.78 | MMP8 (0.73) | MMP8SRRPPARGPKMALDH1A1 | |
| SCHEMBL1312803 | 0.78 | MMP8 (0.62) | MMP8PPARGPKMALDH1A1TP53 | |
| SCHEMBL14503221 | 0.78 | MMP8 (0.60) | MMP8SRRPSAT1PPARAPKM | |
| SCHEMBL6893163 | 0.77 | MMP8 (0.68) | MMP8SRRPPARGPPARAPKM | |
| SCHEMBL15707904 | 0.77 | LMNA (0.62) | MMP8PPARGPPARAALDH1A1PPARD | |
| Hydrochloric Acid SCHEMBL27782844 | 0.77 | SRR (0.54) | MMP8SRRPSAT1PPARGPPARA | |
| Acetic Acid SCHEMBL27782836 | 0.77 | SRR (0.51) | MMP8SRRPSAT1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |