Sugi Predict

Sugi Predict / Compounds / SCHEMBL7362697

SCHEMBL7362697

SCHEMBL7362697

Cc1cc(C(=O)NN)on1

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.67
▸ HCAR2 Q8TDS4 1/20 0.60
▸ NPC1 O15118 1/20 0.58
▸ RAB9A P51151 1/20 0.58
▸ KMT2A Q03164 5/20 0.55
▸ USP2 O75604 1/20 0.54
▸ MEN1 O00255 3/20 0.51
▸ TP53 P04637 2/20 0.51
▸ GLA P06280 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ ALOX12 P18054 1/20 0.49
▸ ALDH1A1 P00352 3/20 0.47
▸ GAA P10253 1/20 0.47
▸ MAPT P10636 2/20 0.46
▸ HPGD P15428 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ VHL P40337 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10274852 0.82 POLB (0.64) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL10274854 0.81 POLB (0.78) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL3740701 0.81 POLB (0.67) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL27283732 0.79 POLB (0.73) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL18896239 0.78 POLB (0.58) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL353474 0.78 — —
SCHEMBL17447460 0.78 POLB (0.82) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL12747057 0.77 ALDH1A1 (0.47) POLBNPC1RAB9AALDH1A1GAA
SCHEMBL10072233 0.76 HCAR2 (0.64) POLBHCAR2NPC1RAB9AKMT2A
SCHEMBL1613078 0.75 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4126869-B1 BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS HOFFMANN LA ROCHE (CH) 2024-06-05 — — EP disclosed
US-20240002393-A1 SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS HOFFMANN-LA ROCHE INC. (US) 2024-01-04 — — US disclosed
US-11739095-B2 Substituted benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepines as GABA A GAMMA1 positive allosteric modulators HOFFMANN-LA ROCHE INC. (US) 2023-08-29 — — US disclosed
EP-4126869-A1 BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS F. Hoffmann-La Roche AG (CH) 2023-02-08 — — EP disclosed
CN-115380034-A Benzodiazepine derivatives as GABA a γ 1 PAM 豪夫迈·罗氏有限公司 2022-11-22 — — CN disclosed
US-20210309664-A1 BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM HOFFMANN-LA ROCHE INC. (US) 2021-10-07 — — US disclosed
WO-2021198124-A1 BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS F. HOFFMANN-LA ROCHE AG (CH) 2021-10-07 — — WO disclosed
US-11046680-B1 Heteroaryl-substituted triazoles as APJ receptor agonists AMGEN INC. (US) 2021-06-29 — — US disclosed
US-11046680-B1 Heteroaryl-substituted triazoles as APJ receptor agonists AMGEN INC. (US) 2021-06-29 — — US disclosed
WO-2021083246-A1 MODIFIER OF FOUR-MEMBERED RING DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2021-05-06 — — WO disclosed
US-8399451-B2 Heterocyclic compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2013-03-19 — — US disclosed
US-8383651-B2 Compounds which selectively modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-02-26 — — US disclosed
US-8383651-B2 Compounds which selectively modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-02-26 — — US disclosed
US-20110190255-A1 HETEROCYCLIC COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY 2011-08-04 — — US disclosed
WO-2011037795-A1 COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-31 — — WO disclosed
US-20110071196-A1 Compounds Which Selectively Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-24 — — US disclosed
US-20110071196-A1 Compounds Which Selectively Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-24 — — US disclosed
EP-1235829-A2 PYRAZOLO 1,5-D] 1,2,4]TRIAZINES FOR ENHANCING COGNITION MERCK SHARP & DOHME LTD. (GB) 2002-09-04 — — EP disclosed
US-6355638-B1 COGNITION ACTIVATORS MERCK SHARP & DOHME LTD. (GB) 2002-03-12 — — US disclosed
WO-2001038331-A2 PYRAZOLO[1,5-D][1,2,4]TRIAZINES FOR ENHANCING COGNITION MERCK SHARP & DOHME LIMITED (GB) 2001-05-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11046680-B1 Heteroaryl-substituted triazoles as APJ receptor agonists AGTR1, AGTR2, TBXA2R POLB 4304/4885HCAR2 97/4885NPC1 1403/4885
US-20210309664-A1 BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM GABRA1, GABRB1, GABRG1 POLB 2090/4885HCAR2 410/4885NPC1 1733/4885
US-20110190255-A1 HETEROCYCLIC COMPOUNDS S1PR1, S1PR3, S1PR5 POLB 3979/4885HCAR2 248/4885NPC1 869/4885
US-20110071196-A1 Compounds Which Selectively Modulate The CB2 Receptor CNR2, CNR1, OPRL1 POLB 4331/4885HCAR2 77/4885NPC1 1324/4885
US-11739095-B2 Substituted benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepines as GABA A GAMMA1 positive allosteric modulators GABRA1, GABRB1, GABRG1 POLB 3593/4885HCAR2 604/4885NPC1 3598/4885
US-20240002393-A1 SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS GABRA4, GABRB1, GABRB3 POLB 3777/4885HCAR2 510/4885NPC1 4491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.