Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401588 | 0.87 | NAALAD2 (0.42) | MEN1KMT2AGRM2GRM3ALDH1A1 | |
| SCHEMBL7364668 | 0.85 | ANPEP (0.37) | FOLH1MEN1KMT2AGRM2GRM3 | |
| SCHEMBL7396691 | 0.85 | TSHR (0.36) | FOLH1MEN1KMT2AGRM2GRM3 | |
| SCHEMBL7361675 | 0.85 | CA1 (0.41) | HSD11B1KMT2APTGFRALDH1A1CYP1A2 | |
| SCHEMBL7399249 | 0.85 | GABBR2 (0.39) | HSD11B1MEN1KMT2ACYP1A2 | |
| SCHEMBL7367783 | 0.82 | HTT (0.37) | HSD11B1TBXA2RGRM2GRM3 | |
| SCHEMBL7363863 | 0.79 | CNR2 (0.36) | MEN1KMT2AGRM2GRM3PTGER1 | |
| SCHEMBL7367347 | 0.79 | GRM2 (0.37) | MEN1KMT2AGRM2GRM3ALDH1A1 | |
| SCHEMBL7364859 | 0.77 | ANPEP (0.43) | FOLH1GRM2GRM3ALDH1A1CYP1A2 | |
| SCHEMBL7400114 | 0.77 | SLC6A9 (0.41) | GRM2GRM3PTGER1PTGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |