Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 4/20 | 0.49 |
| ▸ | LTA4H | P09960 | 3/20 | 0.49 |
| ▸ | ANPEP | P15144 | 2/20 | 0.47 |
| ▸ | ECE1 | P42892 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370001 | 1.00 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2ATSHR | |
| SCHEMBL7367162 | 0.85 | NAALAD2 (0.58) | MEN1KMT2AMME | |
| SCHEMBL7367157 | 0.85 | NAALAD2 (0.58) | MEN1KMT2AMME | |
| SCHEMBL7367862 | 0.80 | MME (0.54) | MEN1KMT2ACYP1A2MMEECE1 | |
| SCHEMBL7370109 | 0.79 | MEN1 (0.48) | MEN1KMT2ACYP1A2MMEANPEP | |
| SCHEMBL7366443 | 0.77 | MME (0.51) | MMEECE1ACE | |
| SCHEMBL10791413 | 0.77 | LTA4H (0.61) | MMELTA4HANPEPECE1ACE | |
| SCHEMBL7365324 | 0.77 | MME (0.66) | MEN1KMT2ACYP1A2MMEANPEP | |
| SCHEMBL7364836 | 0.75 | ROCK2 (0.51) | — | |
| SCHEMBL7443024 | 0.75 | PIN1 (0.49) | MEN1KMT2ACYP1A2MMEANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | claimed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | claimed |
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |