Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ATP4A | P20648 | 1/20 | 0.36 |
| ▸ | ATP4B | P51164 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361207 | 0.81 | KMT2A (0.45) | POLBCYP2D6DAGLA | |
| SCHEMBL7511580 | 0.80 | LMNA (0.42) | CYP2D6DAGLA | |
| SCHEMBL7843449 | 0.80 | PDE4A (0.40) | CYP2D6DAGLA | |
| SCHEMBL7378633 | 0.78 | TSHR (0.49) | NOS3NOS1NOS2POLBCYP2D6 | |
| SCHEMBL6997571 | 0.71 | ALDH1A1 (0.38) | POLBMAOB | |
| SCHEMBL2883347 | 0.70 | ADORA3 (0.42) | POLBSIGMAR1 | |
| SCHEMBL6996007 | 0.70 | PDE4A (0.41) | CYP2D6 | |
| SCHEMBL27481625 | 0.70 | L3MBTL1 (0.34) | SIGMAR1MAOB | |
| SCHEMBL7893458 | 0.70 | RIPK2 (0.46) | CYP2D6 | |
| SCHEMBL27468086 | 0.69 | GAA (0.52) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107968-A2 | DIHYDRO-[1,2,3]TRIAZOLO-[4,5-D]PYRIMIDIN-7-ONE | BAYER AG (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012504-A2 | DIHYDRO-[1,2,3]TRIAZOLO-[4,5-D]PYRIMIDIN-7-ONE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-03-09 | — | — | WO | disclosed |