SCHEMBL738580

SCHEMBL738580

OB(O)Oc1cccc(OC(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
ALOX15 P16050 1/20 0.42
TSHR P16473 1/20 0.42
HTT P42858 1/20 0.42
CETP P11597 2/20 0.42
GPR3 P46089 2/20 0.40
NOTUM Q6P988 1/20 0.39
KIF11 P52732 2/20 0.39
KAT6A Q92794 1/20 0.38
P2RX1 P51575 1/20 0.38
FFAR1 O14842 1/20 0.38
F10 P00742 1/20 0.38
HDAC8 Q9BY41 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3147185 0.85 GPR3 (0.50) CETPGPR3KIF11
SCHEMBL6677730 0.85 ENPP2 (0.41) ALDH1A1GAAMAPTTSHRF10
SCHEMBL30666641 0.81 MAPT (0.35) ALDH1A1GAAMAPTHPGDALOX15
SCHEMBL630440 0.79 MAPT (0.48) ALDH1A1GAAMAPTALOX15TSHR
SCHEMBL28261 0.78 ENPP2 (0.58) ALDH1A1CETPGPR3KAT6A
SCHEMBL27921960 0.78 MEP1B (0.43) GAAMAPTALOX15TSHRHTT
SCHEMBL737221 0.78 MGLL (0.53) MAPTTSHR
SCHEMBL2413223 0.78 MAPT (0.46) ALDH1A1GAAMAPTHTTCETP
SCHEMBL3146332 0.77 GPR3 (0.44) ALDH1A1GAAMAPTHPGDALOX15
SCHEMBL29719732 0.75 CA1 (0.58) ALDH1A1GAAMAPTCETPF10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036736-A Pyrrolo [2,3-d ] pyrimidine derivative, synthetic method and application 云南大学 2026-05-15 CN disclosed
CN-119528804-A 2- { [2- (Phenoxymethyl) pyridin-5-yl ] oxy } ethanamine derivatives and related compounds as pest control agents, for example, for protecting plants 发现号收购集团 2025-02-28 CN disclosed
CN-119285538-A 2- { [2- (Phenoxymethyl) pyridin-5-yl ] oxy } ethanamine derivatives and related compounds as pest control agents, for example, for protecting plants 发现号收购集团 2025-01-10 CN disclosed
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2023-11-09 US disclosed
CN-105408325-B cyanotriazole compounds 大塚制药株式会社 2019-10-22 CN disclosed
CN-110337295-A Compounds and methods of their use 普拉克西斯精密药物股份有限公司 2019-10-15 CN disclosed
CN-110062761-A Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and their use as GLUN2B receptor modulators 詹森药业有限公司 2019-07-26 CN disclosed
CN-104870422-B Amine derivative or its salt 富士胶片富山化学株式会社 2019-03-15 CN disclosed
CN-105764901-B As for treating pyrido [4,3-B] pyrazine -2- formamides of the neurogenic medicine of neurodegenerative disease 豪夫迈·罗氏有限公司 2018-06-22 CN disclosed
CN-107739338-A Formamide and urea derivative as capsaicin analog receptors ligand 美迪福伦DBT有限公司 2018-02-27 CN disclosed
CN-101384554-B Pyridine-2-carboxamide derivatives HOFFMANN LA ROCHE 2012-08-08 CN disclosed
US-8138213-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-03-20 US disclosed
CN-102333569-A Amine or amino alcohols as glyt1 inhibitors HOFFMANN LA ROCHE 2012-01-25 CN disclosed
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-10-13 US disclosed
US-8026370-B2 Peroxisome proliferator antagonist; hyperlipemia agents; arteriosclerosis; antiischemic agents MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-09-27 US disclosed
US-8022089-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-09-20 US disclosed
CN-101765430-A Novel pyrazole derivatives HOFFMANN LA ROCHE 2010-06-30 CN disclosed
CN-101384554-A Pyridine-2-carboxamide derivatives HOFFMANN LA ROCHE (CH) 2009-03-11 CN disclosed
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof MITSUBISHI PHAMA CORPORATION (JP) 2008-07-10 US disclosed
EP-1816128-A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF Mitsubishi Pharma Corporation (JP) 2007-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof PPARA, PPARD, PPARG ALDH1A1 175/4885GAA 684/4885MAPT 3435/4885
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE HDAC7, ACHE, BRDT ALDH1A1 865/4885GAA 1786/4885MAPT 1692/4885
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CBR3, CHRM1, CBR1 ALDH1A1 1983/4885GAA 4829/4885MAPT 4839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.