Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418439 | 0.85 | HSD11B1 (0.55) | NPC1KMT2A | |
| SCHEMBL7411261 | 0.84 | SLC6A3 (0.46) | NPC1KMT2ASLC6A3PANK3SMN1; SMN2 | |
| SCHEMBL7407232 | 0.83 | FAAH (0.51) | GLANPC1KMT2AFAAHMEN1 | |
| SCHEMBL7412601 | 0.78 | CCR3 (0.65) | — | |
| SCHEMBL7411353 | 0.78 | RPS6KB1 (0.40) | KMT2ASLC6A3KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7322620 | 0.76 | KDM4E (0.61) | NPC1KMT2AFAAHKDM4EPOLB | |
| Water SCHEMBL7408541 | 0.76 | POLB (0.47) | KMT2AFAAHSLC6A3POLBSMN1; SMN2 | |
| SCHEMBL7410409 | 0.75 | PKM (0.55) | KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL23848213 | 0.74 | CYP1A2 (0.54) | GLANPC1KMT2AFAAHSLC6A3 | |
| SCHEMBL8252174 | 0.74 | ALDH1A1 (0.63) | NPC1FAAHKDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198449-A | N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents | A. H. ROBINS COMPANY INCORPORATED (US) | 1993-03-30 | — | — | US | disclosed |