Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369758 | 0.78 | GPR3 (0.41) | LIMK1IKBKBALDH1A1MAPTKDM4E | |
| SCHEMBL787663 | 0.78 | HSD11B1 (0.43) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL5986359 | 0.75 | GPR3 (0.39) | ALDH1A1KDM4EHSD17B10HPGDALOX15 | |
| SCHEMBL2165461 | 0.73 | LMNA (0.43) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL7384536 | 0.70 | L3MBTL1 (0.43) | ALDH1A1MAPTSMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL21036143 | 0.70 | LIMK1 (0.50) | LIMK1IKBKBGABRA1GABRA5ALDH1A1 | |
| SCHEMBL3769911 | 0.69 | GPR3 (0.55) | LIMK1IKBKBGABRA1GABRA5ALDH1A1 | |
| Sulfamide SCHEMBL27870293 | 0.68 | KDM4E (0.56) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL1575935 | 0.68 | HSD11B1 (0.44) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL10371680 | 0.68 | CA2 (0.50) | LIMK1IKBKBALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233958-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001038322-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-05-31 | — | — | WO | disclosed |