Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27532903 | 0.72 | KCNN4 (0.38) | PKMESR1ALDH1A1CA12CA9 | |
| SCHEMBL6403890 | 0.72 | HTR6 (0.50) | PKMALDH1A1CA12CA9 | |
| Biphenyl SCHEMBL5706278 | 0.69 | CA2 (0.47) | CA12CA9LMNA | |
| SCHEMBL812682 | 0.68 | PKM (0.79) | PKMESR1ALDH1A1CA12CA9 | |
| Naphthalene SCHEMBL7850037 | 0.67 | LMNA (0.41) | CA12CA9LMNA | |
| SCHEMBL129629 | 0.66 | PKM (0.56) | PKMESR1ALDH1A1ALOX15CA12 | |
| SCHEMBL4804428 | 0.66 | — | — | |
| SCHEMBL29114329 | 0.61 | NPSR1 (0.45) | ALDH1A1KCNN4KCNA5 | |
| SCHEMBL11595292 | 0.61 | PKM (0.50) | PKMESR1ALDH1A1ALOX15CA12 | |
| SCHEMBL5500613 | 0.61 | PKM (0.50) | PKMESR1ALDH1A1ALOX15CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165472-A4 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-1165472-A1 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056685-A1 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-28 | — | — | WO | disclosed |