Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447468 | 0.72 | TGFBR1 (0.46) | TGFBR1MAPK14HSD17B10IDH1MAPT | |
| SCHEMBL7394296 | 0.71 | TGFBR1 (0.38) | TGFBR1MAPK14HSD17B10IDH1MAPT | |
| SCHEMBL7448201 | 0.70 | EPHX2 (0.39) | TGFBR1MAPK14IDH1MAPTLMNA | |
| SCHEMBL7449699 | 0.69 | MLLT1 (0.38) | TGFBR1MAPK14IDH1MAPTLMNA | |
| SCHEMBL16268845 | 0.69 | TGFBR1 (0.41) | TGFBR1MAPK14HSD17B10IDH1MAPT | |
| SCHEMBL7454383 | 0.69 | CCNA2 (0.38) | TGFBR1NAMPTMAPTLMNANPC1 | |
| SCHEMBL1269573 | 0.67 | KLK1 (0.61) | TGFBR1HSD17B10MAPTLMNAKDM4E | |
| SCHEMBL7556078 | 0.67 | DGAT2 (0.35) | TGFBR1IDH1MAPTLMNAKDM4E | |
| SCHEMBL7448981 | 0.67 | ALDH1A1 (0.43) | MAPTLMNASMN1; SMN2FABP1ALDH1A1 | |
| SCHEMBL7394949 | 0.66 | ALDH1A1 (0.43) | TGFBR1HSD17B10MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966454-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037075-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-08-27 | — | — | WO | disclosed |