Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448201 | 0.70 | EPHX2 (0.39) | DGAT2TGFBR1IDH1ALDH1A1NPC1 | |
| SCHEMBL7423476 | 0.69 | ITK (0.47) | ALDH1A1NPC1LMNAMAPTMAPK1 | |
| SCHEMBL6455288 | 0.69 | MLLT1 (0.33) | DGAT2TGFBR1MLLT1 | |
| SCHEMBL7449699 | 0.68 | MLLT1 (0.38) | DGAT2TGFBR1IDH1ALDH1A1NPC1 | |
| SCHEMBL7448750 | 0.68 | PDE2A (0.36) | TGFBR1IDH1PAX8ALDH1A1NPC1 | |
| SCHEMBL7449392 | 0.67 | NPC1 (0.34) | TGFBR1PAX8ALDH1A1NPC1LMNA | |
| SCHEMBL7445307 | 0.67 | TGFBR1 (0.40) | TGFBR1IDH1ALDH1A1NPC1LMNA | |
| SCHEMBL7556081 | 0.67 | DGAT2 (0.38) | DGAT2ALDH1A1NPC1MLLT1KDM4E | |
| SCHEMBL16268845 | 0.67 | TGFBR1 (0.41) | TGFBR1IDH1ALDH1A1NPC1LMNA | |
| SCHEMBL7447468 | 0.66 | TGFBR1 (0.46) | TGFBR1IDH1ALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |