Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9082309 | 0.97 | LTA4H (0.38) | CASP1LTA4HKCNH2ALDH1A1THRB | |
| SCHEMBL9115852 | 0.85 | FKBP1A (0.33) | ALDH1A1 | |
| SCHEMBL5871698 | 0.76 | ALDH1A1 (0.41) | CASP1ALDH1A1 | |
| SCHEMBL7448545 | 0.74 | SMN1; SMN2 (0.53) | LTA4HALDH1A1 | |
| SCHEMBL6947156 | 0.72 | CASP1 (0.53) | CASP1ALDH1A1 | |
| SCHEMBL9204131 | 0.71 | CTSL (0.36) | ALDH1A1 | |
| SCHEMBL1286296 | 0.71 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL9796122 | 0.70 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL6969799 | 0.70 | SMN1; SMN2 (0.61) | CYP2D6 | |
| SCHEMBL4585565 | 0.69 | LTA4H (0.60) | LTA4HKCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559131-A | ANTAGONISTS OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA | ZENECA LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| EP-0667858-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1995-08-23 | — | — | EP | disclosed |