SCHEMBL7450667

SCHEMBL7450667

CC(C)CCC(=O)CCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.54
PKM P14618 1/20 0.54
KEAP1 Q14145 1/20 0.53
TRPA1 O75762 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
ALOX5 P09917 1/20 0.51
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
FFAR1 O14842 1/20 0.50
HPGD P15428 1/20 0.49
TSHR P16473 1/20 0.49
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
TRPV1 Q8NER1 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572384 0.89 LMNA (0.63) ALDH1A1LMNAPKMTRPA1TDP1
SCHEMBL6571377 0.88 LMNA (0.57) ALDH1A1LMNAPKMTRPA1ALOX5
SCHEMBL6570937 0.86 MAPT (0.59) ALDH1A1LMNAPKMTRPA1ALOX5
SCHEMBL13817696 0.86 ALDH1A1 (0.52) ALDH1A1LMNAPKMKEAP1TRPA1
SCHEMBL497371 0.84 KEAP1 (0.73) ALDH1A1KEAP1TRPA1TDP1L3MBTL1
SCHEMBL105937 0.83 L3MBTL1 (0.54) ALDH1A1LMNAPKMTDP1L3MBTL1
SCHEMBL110046 0.83 TRPA1 (0.64) ALDH1A1KEAP1TRPA1TDP1L3MBTL1
SCHEMBL712597 0.82 KEAP1 (0.70) ALDH1A1KEAP1TRPA1TDP1L3MBTL1
SCHEMBL107423 0.82 KEAP1 (0.70) ALDH1A1KEAP1TRPA1TDP1L3MBTL1
SCHEMBL9765869 0.81 ALDH1A1 (0.64) ALDH1A1KEAP1TRPA1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001079177-A1 CYCLIC DIAZA COMPOUNDS FOR TREATING NEURODEGENERATIVE DISORDERS GPI NIL HOLDINGS, INC. (US) 2001-10-25 WO disclosed
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed