SCHEMBL7463281

SCHEMBL7463281

Cc1ccc(S(=O)(=O)N(C(=O)[C@H]2NCCS2)[C@@H](Cc2ccccc2)C(=O)O)cc1.Cc1ccc(S(=O)(=O)N2CSCC2C(=O)O)cc1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 4/20 0.38
MMP9 P14780 1/20 0.38
ACE P12821 2/20 0.36
ACE2 Q9BYF1 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CAPN1 P07384 4/20 0.35
CTSB P07858 1/20 0.35
ADAMTS5 Q9UNA0 1/20 0.34
FKBP1A P62942 3/20 0.34
KEAP1 Q14145 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7069676 0.87 ADAMTS5 (0.43) MMP9ALDH1A1ADAMTS5KEAP1
SCHEMBL7069725 0.78 LMNA (0.40) ALDH1A1ADAMTS5KEAP1
SCHEMBL7320271 0.75 ITGB3 (0.37) MMP9ALDH1A1
SCHEMBL7070854 0.73 MMP2 (0.56) MMP2MMP9ALDH1A1
SCHEMBL7069746 0.73 ADAMTS5 (0.46) MMP9ACEACE2ALDH1A1ADAMTS5
SCHEMBL7385520 0.72 TAS2R14 (0.41) ADAMTS5KEAP1
SCHEMBL3856501 0.68 TAS2R14 (0.35) ALDH1A1ADAMTS5KEAP1
SCHEMBL7069483 0.68 NPSR1 (0.41) MMP9ALDH1A1ADAMTS5KEAP1
SCHEMBL7421577 0.66 MMP9 (0.37) MMP9ALDH1A1ADAMTS5
SCHEMBL3850724 0.66 P2RX7 (0.33) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001975-A1 BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP disclosed
WO-1999006436-A1 BENZYL COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed