Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 5/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461028 | 0.82 | NHERF1 (0.48) | NHERF1PYGLGABRA1GABRB2F7 | |
| SCHEMBL7461248 | 0.82 | NHERF1 (0.51) | NHERF1PYGLGABRA1GABRB2KMT2A | |
| SCHEMBL28413029 | 0.77 | GABRA1 (0.48) | NHERF1GABRA1GABRB2KMT2AF7 | |
| SCHEMBL2649037 | 0.77 | SPR (0.53) | NHERF1KMT2ALMNA | |
| SCHEMBL26204080 | 0.76 | NR4A2 (0.64) | GABRA1GABRB2KMT2ANR4A2 | |
| SCHEMBL30088334 | 0.72 | CSNK2A1 (0.54) | CSNK2A1 | |
| SCHEMBL21805770 | 0.72 | CSNK2A1 (0.54) | CSNK2A1 | |
| SCHEMBL474836 | 0.71 | ALDH1A1 (0.66) | GABRA1GABRB2KMT2ALMNARAB9A | |
| SCHEMBL8785278 | 0.70 | HTR1A (0.67) | CSNK2A1KMT2A | |
| SCHEMBL7455707 | 0.70 | MAPT (0.45) | NHERF1GABRA1GABRB2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |