Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474441 | 0.81 | ALDH1A1 (0.47) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL8639690 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL8636262 | 0.80 | KMT2A (0.46) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL8636087 | 0.78 | MAPT (0.51) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL7476700 | 0.77 | HTT (0.49) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL8635142 | 0.76 | GSTP1 (0.43) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL11554301 | 0.75 | NPC1 (0.65) | SMN1; SMN2CYP1A2HTTALDH1A1LMNA | |
| SCHEMBL20982472 | 0.73 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTCYP1A2HTTALDH1A1 | |
| SCHEMBL7040592 | 0.72 | LMNA (0.54) | MAPTHTTALDH1A1LMNANPC1 | |
| SCHEMBL7475387 | 0.72 | MAPT (0.61) | SMN1; SMN2MAPTHTTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |