Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL7490478 | 0.92 | POLB (0.44) | MAPTKDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL7489529 | 0.81 | ALDH1A1 (0.43) | MAPTKDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL7487377 | 0.80 | LMNA (0.40) | MAPTKDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL7490464 | 0.80 | LMNA (0.41) | MAPTKDM4ESMN1; SMN2LMNAPOLB | |
| Diethylamine SCHEMBL8136070 | 0.75 | PDE4A (0.56) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| Diethylamine SCHEMBL7485928 | 0.74 | ABCG2 (0.54) | MAPTKDM4EALDH1A1HPGDSLC10A2 | |
| SCHEMBL1901332 | 0.70 | LMNA (0.61) | MAPTKDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL10690098 | 0.67 | L3MBTL1 (0.51) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7493208 | 0.65 | SLC10A2 (0.50) | MAPTKDM4ESMN1; SMN2ALDH1A1SLC10A2 | |
| Hydrochloric Acid SCHEMBL5475286 | 0.64 | MAPT (0.53) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791000-B1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-02 | — | — | EP | claimed |
| EP-0791000-B1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| EP-0791000-A1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996014319-A1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-17 | — | — | WO | disclosed |