Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745530 | 0.93 | HDAC1 (0.41) | LPAR1LPAR5SRCNPC1MEN1 | |
| SCHEMBL750906 | 0.92 | TP53 (0.39) | LPAR1LPAR5SRCMEN1KMT2A | |
| SCHEMBL747722 | 0.92 | ESRRG (0.41) | SRCHDAC1HDAC6HIF1AALDH1A1 | |
| SCHEMBL746738 | 0.92 | SRC (0.36) | LPAR1LPAR5SRCHDAC1HDAC6 | |
| SCHEMBL751065 | 0.91 | SRC (0.38) | SRCMEN1KMT2AHDAC1HDAC6 | |
| SCHEMBL749647 | 0.91 | LMNA (0.39) | NPC1MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL750133 | 0.89 | SRC (0.36) | LPAR1LPAR5SRCMEN1KMT2A | |
| SCHEMBL747958 | 0.88 | TP53 (0.38) | LPAR1LPAR5SRCMEN1KMT2A | |
| SCHEMBL750950 | 0.87 | SRC (0.36) | SRCNR1H4HDAC1HDAC6HIF1A | |
| SCHEMBL748197 | 0.87 | SRC (0.36) | LPAR1LPAR5SRCHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |