Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 14/20 | 0.77 |
| ▸ | PDE4B known ✓ | Q07343 | 14/20 | 0.77 |
| ▸ | PDE4D known ✓ | Q08499 | 14/20 | 0.77 |
| ▸ | PDE4C known ✓ | Q08493 | 13/20 | 0.77 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440108 | 0.87 | PDE4B (1.00) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL8885266 | 0.87 | PDE4B (0.81) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7444846 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7501628 | 0.86 | PDE4A (0.97) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL8461881 | 0.86 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL8466031 | 0.84 | PDE4A (0.75) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7451207 | 0.84 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5823060 | 0.83 | PDE4A (0.77) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7447872 | 0.82 | PDE4B (0.77) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL8464657 | 0.80 | PDE4B (0.73) | PDE4APDE4BPDE4DPDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5691376-A | ANTIHISTAMINE, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-25 | — | — | US | disclosed |
| US-5650444-A | BRONCHODILATOR AGENTS, ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-07-22 | — | — | US | disclosed |
| EP-0745063-A1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995022520-A1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-08-24 | — | — | WO | disclosed |