SCHEMBL7525313

SCHEMBL7525313

COc1cc[c]c2c1-c1ccccc1C2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.40
ALDH1A1 P00352 5/20 0.40
KDM4E B2RXH2 5/20 0.40
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
PTGS2 P35354 1/20 0.40
USP2 O75604 1/20 0.40
DUSP3 P51452 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
RAB9A P51151 3/20 0.38
GAA P10253 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NPC1 O15118 1/20 0.38
CASP3 P42574 1/20 0.38
CASP6 P55212 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
HTR2C P28335 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2047396 0.78 MAOA (0.35) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL2045382 0.74 MAOA (0.32) ALDH1A1BCHECES1
SCHEMBL7520085 0.74 ALDH1A1 (0.37) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL3286498 0.74 PTGS2 (0.49) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL2050046 0.73 ADORA2A (0.37) ALDH1A1DRD2BCHECES1MAPK1
SCHEMBL5080844 0.72 PNMT (0.31) RAB9ANPC1
Ethylene SCHEMBL7873619 0.71 PTGS2 (0.46) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL5086942 0.69 NR1H2 (0.36) ALDH1A1HTR2CDRD2
SCHEMBL285403 0.69 APAF1 (0.34) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL4652057 0.68 NR1H2 (0.38) ALDH1A1GAAHTR2CDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773238-B1 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY (US) 2002-03-20 EP claimed
EP-0773239-B1 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY (US) 2001-12-05 EP claimed
EP-0773238-B1 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY (US) 2002-03-20 EP disclosed
US-5688735-A COORDINATION CATALYST FINA TECHNOLOGY, INC. (US) 1997-11-18 US disclosed