Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28528072 | 0.89 | CYP1A1 (0.44) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL29149633 | 0.80 | TSHR (0.52) | ALDH1A1TSHRKIF11 | |
| SCHEMBL287478 | 0.78 | ALDH1A1 (0.48) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL15661104 | 0.78 | ALDH1A1 (0.48) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL63468 | 0.76 | ALDH1A1 (0.67) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL31325622 | 0.76 | ALDH1A1 (0.46) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL5713308 | 0.76 | ALDH1A1 (0.46) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL7798387 | 0.74 | CES2 (0.46) | CES2ALDH1A1TSHR | |
| SCHEMBL1305145 | 0.74 | TSHR (0.48) | ALDH1A1TSHRKIF11SRD5A2CA1 | |
| SCHEMBL19968564 | 0.74 | ALDH1A1 (0.43) | CES2CES1ALDH1A1TSHRKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114031639-B | Preparation method of biphospide with P-O-C-P structure | 烟台大学 | 2024-07-12 | — | — | CN | claimed |
| CN-113583042-B | Preparation method of phosphoryl fluoride compound | 烟台大学 | 2023-08-29 | — | — | CN | claimed |
| CN-113583042-A | Preparation method of phosphoryl fluoride compound | 烟台大学 | 2021-11-02 | — | — | CN | claimed |
| CN-118908996-A | A composition containing C (sp2) P bond or C (sp)3) Process for preparing organic phosphine compound of-P bond | 烟台大学 | 2024-11-08 | — | — | CN | disclosed |
| CN-118652272-A | Method for synthesizing thiophosphorus/phosphinic acid ester compound | 中国人民解放军军事科学院防化研究院 | 2024-09-17 | — | — | CN | disclosed |
| CN-114031639-B | Preparation method of biphospide with P-O-C-P structure | 烟台大学 | 2024-07-12 | — | — | CN | disclosed |
| CN-113583042-B | Preparation method of phosphoryl fluoride compound | 烟台大学 | 2023-08-29 | — | — | CN | disclosed |
| CN-114031639-A | Preparation method of biphosphonate with P-O-C-P structure | 烟台大学 | 2022-02-11 | — | — | CN | disclosed |
| CN-113583042-A | Preparation method of phosphoryl fluoride compound | 烟台大学 | 2021-11-02 | — | — | CN | disclosed |
| CN-109096331-B | Method for preparing o-diaryl phosphoryl substituted phenol derivative | 湖南理工学院 | 2021-10-01 | — | — | CN | disclosed |
| US-10328089-B2 | Fumagillol derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-06-25 | — | — | US | disclosed |
| US-20180050051-A1 | FUMAGILLOL DERIVATIVES | TAKEDA CALIFORNIA, INC. | 2018-02-22 | — | — | US | disclosed |
| US-9827255-B2 | Fumagillol derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-11-28 | — | — | US | disclosed |
| EP-3233870-A1 | FUMAGILLOL DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2017-10-25 | — | — | EP | disclosed |
| US-20170233418-A1 | N-(PHOSPHINOALKYL)-N-(THIOALKYL)AMINE DERIVATIVE, METHOD FOR PRODUCING SAME, AND METAL COMPLEX THEREOF | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2017-08-17 | — | — | US | disclosed |
| US-20160175332-A1 | FUMAGILLOL DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) | 2016-06-23 | — | — | US | disclosed |
| WO-2016100778-A1 | FUMAGILLOL DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-23 | — | — | WO | disclosed |
| EP-0754696-B1 | Unsymmetric diphosphine monoxide compounds and a process for preparing diphosphine compounds | TAKASAGO PERFUMERY CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5808162-A | Chiral unsymmetric diphosphine compound and transition metal complex containing the same as ligand | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1998-09-15 | — | — | US | disclosed |
| EP-0754696-A1 | Chiral unsymmetric diphosphine compounds and transition metal complexes containing them as ligands | Takasago International Corporation (JP) | 1997-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233418-A1 | N-(PHOSPHINOALKYL)-N-(THIOALKYL)AMINE DERIVATIVE, METHOD FOR PRODUCING SAME, AND METAL COMPLEX THEREOF | NSFL1C, TST, NCL | CES2 2520/4885CES1 2909/4885ALDH1A1 1341/4885 |
| US-20160175332-A1 | FUMAGILLOL DERIVATIVES | SULT2A1, METAP2, FAH | CES2 335/4885CES1 332/4885ALDH1A1 315/4885 |
| US-20180050051-A1 | FUMAGILLOL DERIVATIVES | SULT2A1, METAP2, FAH | CES2 335/4885CES1 332/4885ALDH1A1 315/4885 |
| US-10328089-B2 | Fumagillol derivatives | SULT2A1, METAP2, FAH | CES2 335/4885CES1 332/4885ALDH1A1 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.