Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | DRD3 | P35462 | 2/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 6/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | GOT1 | P17174 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791195 | 0.91 | DRD2 (0.61) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL5113532 | 0.86 | DRD2 (0.65) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL7732059 | 0.86 | DRD2 (0.69) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL29046800 | 0.83 | DRD2 (0.66) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL23102103 | 0.82 | DRD2 (0.68) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL3208122 | 0.82 | DRD2 (0.57) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL17817484 | 0.81 | DRD2 (0.60) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL4306478 | 0.80 | ADRB1 (0.69) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL2161623 | 0.80 | DRD2 (0.58) | DRD2DRD3DRD4GAAHTR6 | |
| SCHEMBL6686430 | 0.80 | HTR6 (0.72) | DRD2DRD3DRD4GAAHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1342152-A | N-substituted imide derivatives having 5-hydroxytryptamine activity | AMERICAN HOME PROD (US) | 2002-03-27 | — | — | CN | disclosed |
| US-20020013324-A1 | N-substituted imide derivatives with serotonergic activity | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-31 | — | — | US | disclosed |
| EP-1157017-A1 | N-SUBSTITUTED IMIDE DERIVATIVES WITH SEROTONERGIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6306859-B1 | PIPERIDINE ALKYL IMIDES AS NEUROTRANSMITTERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| WO-2000052002-A1 | N-SUBSTITUTED IMIDE DERIVATIVES WITH SEROTONERGIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013324-A1 | N-substituted imide derivatives with serotonergic activity | TPH1, HTR1A, HTR1E | DRD2 43/4885DRD3 70/4885DRD4 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.