Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 6/20 | 0.43 |
| ▸ | CA1 known ✓ | P00915 | 6/20 | 0.43 |
| ▸ | CA2 known ✓ | P00918 | 6/20 | 0.43 |
| ▸ | P2RY4 known ✓ | P51582 | 2/20 | 0.42 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.42 |
| ▸ | P2RY2 known ✓ | P41231 | 1/20 | 0.41 |
| ▸ | P2RY6 known ✓ | Q15077 | 1/20 | 0.41 |
| ▸ | P2RY12 known ✓ | Q9H244 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 8/20 | 0.49 |
| ▸ | CA9 | Q16790 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205537 | 0.89 | P2RY4 (0.53) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL11732193 | 0.88 | RAD51 (0.50) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL30532269 | 0.88 | RAD51 (0.60) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL893765 | 0.88 | RAD51 (0.60) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL11732226 | 0.88 | RAD51 (0.50) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL29737199 | 0.88 | RAD51 (0.60) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL1169584 | 0.88 | RAD51 (0.60) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL1536255 | 0.88 | CA12 (0.56) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL11879420 | 0.88 | CA12 (0.56) | RAD51CA12CA1CA2CA9 | |
| SCHEMBL2218680 | 0.88 | CA12 (0.44) | RAD51CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709724-B1 | Silver halide emulsions with doped epitaxy | EASTMAN KODAK CO (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-0709724-A2 | Silver halide emulsions with doped epitaxy | EASTMAN KODAK COMPANY (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5462849-A | Host grain surface portions exhibit a face centered cubic crystal lattice structure containing a hexacoordination complex | EASTMAN KODAK COMPANY (US) | 1995-10-31 | — | — | US | disclosed |