SCHEMBL754587

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL756220	0.90	JAK2 (0.43)	JAK2JAK3KDM4ETDP1LIPG
	SCHEMBL755319	0.89	JAK2 (0.43)	JAK2JAK3KDM4EALDH1A1TDP1
	SCHEMBL751416	0.88	JAK2 (0.44)	JAK2JAK3KDM4EALDH1A1TDP1
	SCHEMBL753011	0.87	JAK2 (0.45)	JAK2JAK3KDM4ETDP1LIPG
	SCHEMBL751248	0.85	LMNA (0.44)	JAK2JAK3ALDH1A1TDP1LMNA
	SCHEMBL753218	0.83	JAK2 (0.44)	JAK2JAK3KDM4EALDH1A1TDP1
	SCHEMBL754532	0.82	JAK2 (0.43)	JAK2JAK3KDM4ETDP1LIPG
	SCHEMBL753420	0.79	ALDH1A1 (0.39)	KDM4EALDH1A1HPGDTDP1LIPG
	SCHEMBL755973	0.76	PKM (0.41)	JAK2JAK3ALDH1A1HPGDLIPG
	SCHEMBL2487611	0.74	JAK2 (0.46)	JAK2JAK3KDM4ETDP1ELOVL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.