Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SHBG | P04278 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547894 | 0.88 | MAPT (0.46) | MEN1MAPTKMT2ASHBGCNR2 | |
| SCHEMBL8799386 | 0.86 | SHBG (0.44) | MEN1KMT2ASHBGCNR2CTBP2 | |
| SCHEMBL9059987 | 0.83 | SGMS2 (0.35) | MEN1MAPTKMT2ASHBGNR3C2 | |
| SCHEMBL7548395 | 0.81 | ALOX5 (0.38) | NPC1 | |
| SCHEMBL7600813 | 0.80 | — | — | |
| SCHEMBL7548471 | 0.79 | MAPK13 (0.41) | ALDH1A1NOS3NOS1NOS2CTNNB1 | |
| SCHEMBL7546252 | 0.79 | TDP1 (0.32) | NOS3NOS2 | |
| SCHEMBL7546196 | 0.78 | KDM4E (0.38) | KDM4ENOS3NOS2NPC1 | |
| SCHEMBL9063741 | 0.76 | NPC1 (0.39) | ALDH1A1NOS3NOS1NOS2CTNNB1 | |
| SCHEMBL8805065 | 0.75 | SHBG (0.44) | MEN1KMT2ASHBGCNR2CTBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997049708-A9 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | — | 1998-05-22 | — | — | WO | disclosed |
| EP-0811008-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-12-10 | — | — | EP | disclosed |